Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents

Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents

Hippocampal CA1 pyramidal neurons generate an after-hyperpolarization (AHP) whose medium component is thought to be generated by small-conductance Ca2+-activated K+ channels (SK channels). Neuronal excitability is increased in epilepsy, and the AHP in turn is fundamentally involved in regulation of...

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Bibliographic Details
Main Authors: Robert Schulz, Timo Kirschstein, Hannes Brehme, Katrin Porath, Ulrike Mikkat, Rüdiger Köhling
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
Ca2+-activated K+ channel
After-hyperpolarizing potential
Status epilepticus
Patch-clamp
UCL1684
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002853

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