The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques

The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques

Tissue cross-reactivity (TCR) studies are screening immunohistochemical (IHC) assays, usually conducted on frozen human and animal tissues. This study is obligatory for getting the permission for clinical trials in Russia for all innovative therapeutic products based on monoclonal antibodies or anti...

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Main Authors: T. Y. Ostroukhova, V. A. Ivanov, E. L. Morozova, R. A. Ivanov
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-02-01
Series:Биопрепараты: Профилактика, диагностика, лечение
Subjects:
исследование тканевой перекрестной реактивности (кросс-реактивности) препарата (tcr)
моноклональное антитело
иммуногистохимический (игх) анализ
tissue cross-reactivity (tcr) study
monoclonal antibody
immunohistochemical (ihc) assay
Online Access:https://www.biopreparations.ru/jour/article/view/70
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spelling doaj-afafe146eee74a70b1e8760e42a0681c2021-07-28T14:03:34ZrusMinistry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» Биопрепараты: Профилактика, диагностика, лечение2221-996X2619-11562018-02-0116423724470The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniquesT. Y. Ostroukhova0V. A. Ivanov1E. L. Morozova2R. A. Ivanov3CJSC «BIOCAD»CJSC «BIOCAD»CJSC «BIOCAD»CJSC «BIOCAD»Tissue cross-reactivity (TCR) studies are screening immunohistochemical (IHC) assays, usually conducted on frozen human and animal tissues. This study is obligatory for getting the permission for clinical trials in Russia for all innovative therapeutic products based on monoclonal antibodies or antibody-like molecules that contain complementarity-determining region (CDR). In this article are represented approaches and methodical features for successful conduction of tissue cross-reactivity studies with examples from own authors’ experience.https://www.biopreparations.ru/jour/article/view/70исследование тканевой перекрестной реактивности (кросс-реактивности) препарата (tcr)моноклональное антителоиммуногистохимический (игх) анализtissue cross-reactivity (tcr) studymonoclonal antibodyimmunohistochemical (ihc) assay
collection DOAJ
language Russian
format Article
sources DOAJ
author T. Y. Ostroukhova
V. A. Ivanov
E. L. Morozova
R. A. Ivanov
spellingShingle T. Y. Ostroukhova
V. A. Ivanov
E. L. Morozova
R. A. Ivanov
The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques
Биопрепараты: Профилактика, диагностика, лечение
исследование тканевой перекрестной реактивности (кросс-реактивности) препарата (tcr)
моноклональное антитело
иммуногистохимический (игх) анализ
tissue cross-reactivity (tcr) study
monoclonal antibody
immunohistochemical (ihc) assay
author_facet T. Y. Ostroukhova
V. A. Ivanov
E. L. Morozova
R. A. Ivanov
author_sort T. Y. Ostroukhova
title The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques
title_short The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques
title_full The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques
title_fullStr The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques
title_full_unstemmed The study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques
title_sort study of cross-reactivity of therapeutic drugs based on monoclonal antibodies on human tissues: basic approaches and methodological techniques
publisher Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
series Биопрепараты: Профилактика, диагностика, лечение
issn 2221-996X
2619-1156
publishDate 2018-02-01
description Tissue cross-reactivity (TCR) studies are screening immunohistochemical (IHC) assays, usually conducted on frozen human and animal tissues. This study is obligatory for getting the permission for clinical trials in Russia for all innovative therapeutic products based on monoclonal antibodies or antibody-like molecules that contain complementarity-determining region (CDR). In this article are represented approaches and methodical features for successful conduction of tissue cross-reactivity studies with examples from own authors’ experience.
topic исследование тканевой перекрестной реактивности (кросс-реактивности) препарата (tcr)
моноклональное антитело
иммуногистохимический (игх) анализ
tissue cross-reactivity (tcr) study
monoclonal antibody
immunohistochemical (ihc) assay
url https://www.biopreparations.ru/jour/article/view/70
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AT vaivanov thestudyofcrossreactivityoftherapeuticdrugsbasedonmonoclonalantibodiesonhumantissuesbasicapproachesandmethodologicaltechniques
AT elmorozova thestudyofcrossreactivityoftherapeuticdrugsbasedonmonoclonalantibodiesonhumantissuesbasicapproachesandmethodologicaltechniques
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AT tyostroukhova studyofcrossreactivityoftherapeuticdrugsbasedonmonoclonalantibodiesonhumantissuesbasicapproachesandmethodologicaltechniques
AT vaivanov studyofcrossreactivityoftherapeuticdrugsbasedonmonoclonalantibodiesonhumantissuesbasicapproachesandmethodologicaltechniques
AT elmorozova studyofcrossreactivityoftherapeuticdrugsbasedonmonoclonalantibodiesonhumantissuesbasicapproachesandmethodologicaltechniques
AT raivanov studyofcrossreactivityoftherapeuticdrugsbasedonmonoclonalantibodiesonhumantissuesbasicapproachesandmethodologicaltechniques
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