Withaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cells.

Withaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cells.

Currently, the treatment for ovarian cancer entails cytoreductive surgery followed by chemotherapy, mainly, carboplatin combined with paclitaxel. Although this regimen is initially effective in a high percentage of cases, unfortunately within few months of initial treatment, tumor relapse occurs bec...

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Bibliographic Details
Main Authors: Sham S Kakar, Mariusz Z Ratajczak, Karen S Powell, Mana Moghadamfalahi, Donald M Miller, Surinder K Batra, Sanjay K Singh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4180068?pdf=render

Internet

http://europepmc.org/articles/PMC4180068?pdf=render

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