Delivery of Agents Into Articular Cartilage With Electric Spark-Induced Sound Waves

Delivery of Agents Into Articular Cartilage With Electric Spark-Induced Sound Waves

Localized delivery of drugs into articular cartilage (AC) may facilitate the development of novel therapies to treat osteoarthritis (OA). We investigated the potential of spark-gap-generated sound to deliver a drug surrogate, i.e., methylene blue (MB), into AC. In vitro experiments exposed bovine AC...

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Bibliographic Details
Main Authors: Alejandro García Pérez, Heikki J. Nieminen, Mikko Finnilä, Ari Salmi, Kenneth P. H. Pritzker, Eetu Lampsijärvi, Tor Paulin, Anu J. Airaksinen, Simo Saarakkala, Edward Hæggström
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physics
Subjects:
osteoarthritis therapies
electric sparks
cartilage
sound
ultrasound
drug delivery
Online Access:https://www.frontiersin.org/article/10.3389/fphy.2018.00116/full

Internet

https://www.frontiersin.org/article/10.3389/fphy.2018.00116/full

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