4-Oxatricyclo[5.2.1.0<sup>2,6</sup>]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential

4-Oxatricyclo[5.2.1.0<sup>2,6</sup>]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential

The impact of excitotoxicity mediated by <i>N</i>-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development of neurodegenerative disorders. NGP1-01, a polycyclic amine,...

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Bibliographic Details
Main Authors: Ayodeji O. Egunlusi, Sarel F. Malan, Sylvester I. Omoruyi, Okobi E. Ekpo, Jacques Joubert
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
neurodegenerative disorders
4-oxatricyclo[5.2.1.0<sup>2,6</sup>]dec-8-ene-3,5-dione
cytotoxicity
neuroprotection
NMDA receptor
voltage gated calcium channels
Online Access:https://www.mdpi.com/1420-3049/25/19/4552

Internet

https://www.mdpi.com/1420-3049/25/19/4552

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