Anaphylaxis induced by sugammadex and sugammadex-rocuronium complex -a case report-

• Main Authors: Shu Chung Choi, Sangbin Han, Jueun Kwak, Ji Yung Lee
• Format: Article
• Language: English
• Published: Korean Society of Anesthesiologists 2020-08-01
• Series: Korean Journal of Anesthesiology
• Subjects: anaphylaxis; general anesthesia; hypotension; rocuronium; skin test; sugammadex; urticaria
• Online Access: http://ekja.org/upload/pdf/kja-19344.pdf

Background In sugammadex-induced anaphylaxis, sugammadex and/or sugammadex-rocuronium complex have possible allergenic epitope. Case We report a case of sugammadex-induced anaphylaxis during general anesthesia in a 60-year-old male undergoing orthopedic hand surgery, manifesting as profound hypotension and urticaria. The timing of onset was closely associated with sugammadex administration. The patient recovered after extensive therapy including fluid, epinephrine, other vasopressors, steroid, and antihistamine administration. By intradermal skin test which was done at four weeks after anaphylaxis, we confirmed positive reactions to both sugammadex and sugammadex-rocuronium complex. Conclusions This is a rare case of sugammadex-induced anaphylaxis that both sugammadex and sugammadex-rocuronium complex were confirmed as allergenic epitopes.