The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients
Background: Liver biopsy, which is considered the best method for evaluating hepatic fibrosis, has important adverse events. Therefore, non-invasive tests have been developed to determine the degree of hepatic fibrosis in patients with chronic hepatitis B. Aim: To verify the usefulness of a new fibr...
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doaj-b141aeaa1f224f1fa1c1af44cc439f102020-11-25T01:47:57ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082015-12-0110712740744S1130-01082015001200004The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patientsBanu Demet Coskun0Engin Altınkaya1Eylem Sevinc2Mustafa Ozen3Hatice Karaman4Ahmet Karaman5Orhan Poyrazoglu6Kayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalBackground: Liver biopsy, which is considered the best method for evaluating hepatic fibrosis, has important adverse events. Therefore, non-invasive tests have been developed to determine the degree of hepatic fibrosis in patients with chronic hepatitis B. Aim: To verify the usefulness of a new fibrosis index the globulin/platelet model in patients with chronic hepatitis B and to compare it with other noninvasive tests for predicting significant fibrosis. This study was the second to evaluate the globulin/platelet model in HBV patients. Methods: We retrospectively investigated 228 patients with chronic hepatitis B who performed liver biopsy from 2013 to 2014. The globulin/platelet model, APGA [AST/Platelet/Gamma-glutamyl transpeptidase/Alfa-fetoprotein], FIB4, fibrosis index, cirrhosis discriminate score, and Fibro-quotient were calculated, and the diagnostic accuracies of all of the fibrosis indices were compared between the F0-2 (no-mild fibrosis) and F3-6 (significant fibrosis) groups. Results: All of the noninvasive markers were significantly correlated with the stage of liver fibrosis (p < 0,001). To predict significant fibrosis (F ≥ 3), the area under the curve (95% CI) was found to be greatest for APGA (0.83 [0.74-0.86]), followed by FIB-4 (0.75[0.69-0.80]), the globulin/platelet model (0.74 [0.68-0.79]), fibrosis index (0.72 [0.6-0.78], cirrhosis discriminate score (0.71 [0.64-0.76]) and Fibro-quotient (0.62 [0.55-0.7]). The area under the receiver operating characteristic curves of APGA was significantly higher than that of the other noninvasive fibrosis markers (p < 0.05). Conclusions: While the APGA index was found to be the most valuable test for the prediction significant fibrosis in patients with chronic hepatitis B, GP model was the thirth valuable test. Therefore, we recommended that APGA could be used instead of the GP model for prediction liver fibrosis.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015001200004&lng=en&tlng=enChronic hepatitis BLiver fibrosisNoninvasive fibrosis markerGlobulin/platelet model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Banu Demet Coskun Engin Altınkaya Eylem Sevinc Mustafa Ozen Hatice Karaman Ahmet Karaman Orhan Poyrazoglu |
spellingShingle |
Banu Demet Coskun Engin Altınkaya Eylem Sevinc Mustafa Ozen Hatice Karaman Ahmet Karaman Orhan Poyrazoglu The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients Revista Espanola de Enfermedades Digestivas Chronic hepatitis B Liver fibrosis Noninvasive fibrosis marker Globulin/platelet model |
author_facet |
Banu Demet Coskun Engin Altınkaya Eylem Sevinc Mustafa Ozen Hatice Karaman Ahmet Karaman Orhan Poyrazoglu |
author_sort |
Banu Demet Coskun |
title |
The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients |
title_short |
The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients |
title_full |
The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients |
title_fullStr |
The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients |
title_full_unstemmed |
The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients |
title_sort |
diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis b patients |
publisher |
Aran Ediciones |
series |
Revista Espanola de Enfermedades Digestivas |
issn |
1130-0108 |
publishDate |
2015-12-01 |
description |
Background: Liver biopsy, which is considered the best method for evaluating hepatic fibrosis, has important adverse events. Therefore, non-invasive tests have been developed to determine the degree of hepatic fibrosis in patients with chronic hepatitis B. Aim: To verify the usefulness of a new fibrosis index the globulin/platelet model in patients with chronic hepatitis B and to compare it with other noninvasive tests for predicting significant fibrosis. This study was the second to evaluate the globulin/platelet model in HBV patients. Methods: We retrospectively investigated 228 patients with chronic hepatitis B who performed liver biopsy from 2013 to 2014. The globulin/platelet model, APGA [AST/Platelet/Gamma-glutamyl transpeptidase/Alfa-fetoprotein], FIB4, fibrosis index, cirrhosis discriminate score, and Fibro-quotient were calculated, and the diagnostic accuracies of all of the fibrosis indices were compared between the F0-2 (no-mild fibrosis) and F3-6 (significant fibrosis) groups. Results: All of the noninvasive markers were significantly correlated with the stage of liver fibrosis (p < 0,001). To predict significant fibrosis (F ≥ 3), the area under the curve (95% CI) was found to be greatest for APGA (0.83 [0.74-0.86]), followed by FIB-4 (0.75[0.69-0.80]), the globulin/platelet model (0.74 [0.68-0.79]), fibrosis index (0.72 [0.6-0.78], cirrhosis discriminate score (0.71 [0.64-0.76]) and Fibro-quotient (0.62 [0.55-0.7]). The area under the receiver operating characteristic curves of APGA was significantly higher than that of the other noninvasive fibrosis markers (p < 0.05). Conclusions: While the APGA index was found to be the most valuable test for the prediction significant fibrosis in patients with chronic hepatitis B, GP model was the thirth valuable test. Therefore, we recommended that APGA could be used instead of the GP model for prediction liver fibrosis. |
topic |
Chronic hepatitis B Liver fibrosis Noninvasive fibrosis marker Globulin/platelet model |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015001200004&lng=en&tlng=en |
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