The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients

Background: Liver biopsy, which is considered the best method for evaluating hepatic fibrosis, has important adverse events. Therefore, non-invasive tests have been developed to determine the degree of hepatic fibrosis in patients with chronic hepatitis B. Aim: To verify the usefulness of a new fibr...

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Main Authors: Banu Demet Coskun, Engin Altınkaya, Eylem Sevinc, Mustafa Ozen, Hatice Karaman, Ahmet Karaman, Orhan Poyrazoglu
Format: Article
Language:English
Published: Aran Ediciones 2015-12-01
Series:Revista Espanola de Enfermedades Digestivas
Subjects:
Online Access:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015001200004&lng=en&tlng=en
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spelling doaj-b141aeaa1f224f1fa1c1af44cc439f102020-11-25T01:47:57ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082015-12-0110712740744S1130-01082015001200004The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patientsBanu Demet Coskun0Engin Altınkaya1Eylem Sevinc2Mustafa Ozen3Hatice Karaman4Ahmet Karaman5Orhan Poyrazoglu6Kayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalKayseri Training and Research HospitalBackground: Liver biopsy, which is considered the best method for evaluating hepatic fibrosis, has important adverse events. Therefore, non-invasive tests have been developed to determine the degree of hepatic fibrosis in patients with chronic hepatitis B. Aim: To verify the usefulness of a new fibrosis index the globulin/platelet model in patients with chronic hepatitis B and to compare it with other noninvasive tests for predicting significant fibrosis. This study was the second to evaluate the globulin/platelet model in HBV patients. Methods: We retrospectively investigated 228 patients with chronic hepatitis B who performed liver biopsy from 2013 to 2014. The globulin/platelet model, APGA [AST/Platelet/Gamma-glutamyl transpeptidase/Alfa-fetoprotein], FIB4, fibrosis index, cirrhosis discriminate score, and Fibro-quotient were calculated, and the diagnostic accuracies of all of the fibrosis indices were compared between the F0-2 (no-mild fibrosis) and F3-6 (significant fibrosis) groups. Results: All of the noninvasive markers were significantly correlated with the stage of liver fibrosis (p < 0,001). To predict significant fibrosis (F ≥ 3), the area under the curve (95% CI) was found to be greatest for APGA (0.83 [0.74-0.86]), followed by FIB-4 (0.75[0.69-0.80]), the globulin/platelet model (0.74 [0.68-0.79]), fibrosis index (0.72 [0.6-0.78], cirrhosis discriminate score (0.71 [0.64-0.76]) and Fibro-quotient (0.62 [0.55-0.7]). The area under the receiver operating characteristic curves of APGA was significantly higher than that of the other noninvasive fibrosis markers (p < 0.05). Conclusions: While the APGA index was found to be the most valuable test for the prediction significant fibrosis in patients with chronic hepatitis B, GP model was the thirth valuable test. Therefore, we recommended that APGA could be used instead of the GP model for prediction liver fibrosis.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015001200004&lng=en&tlng=enChronic hepatitis BLiver fibrosisNoninvasive fibrosis markerGlobulin/platelet model
collection DOAJ
language English
format Article
sources DOAJ
author Banu Demet Coskun
Engin Altınkaya
Eylem Sevinc
Mustafa Ozen
Hatice Karaman
Ahmet Karaman
Orhan Poyrazoglu
spellingShingle Banu Demet Coskun
Engin Altınkaya
Eylem Sevinc
Mustafa Ozen
Hatice Karaman
Ahmet Karaman
Orhan Poyrazoglu
The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients
Revista Espanola de Enfermedades Digestivas
Chronic hepatitis B
Liver fibrosis
Noninvasive fibrosis marker
Globulin/platelet model
author_facet Banu Demet Coskun
Engin Altınkaya
Eylem Sevinc
Mustafa Ozen
Hatice Karaman
Ahmet Karaman
Orhan Poyrazoglu
author_sort Banu Demet Coskun
title The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients
title_short The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients
title_full The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients
title_fullStr The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients
title_full_unstemmed The diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis B patients
title_sort diagnostic value of a globulin/platelet model for evaluating liver fibrosis in chronic hepatitis b patients
publisher Aran Ediciones
series Revista Espanola de Enfermedades Digestivas
issn 1130-0108
publishDate 2015-12-01
description Background: Liver biopsy, which is considered the best method for evaluating hepatic fibrosis, has important adverse events. Therefore, non-invasive tests have been developed to determine the degree of hepatic fibrosis in patients with chronic hepatitis B. Aim: To verify the usefulness of a new fibrosis index the globulin/platelet model in patients with chronic hepatitis B and to compare it with other noninvasive tests for predicting significant fibrosis. This study was the second to evaluate the globulin/platelet model in HBV patients. Methods: We retrospectively investigated 228 patients with chronic hepatitis B who performed liver biopsy from 2013 to 2014. The globulin/platelet model, APGA [AST/Platelet/Gamma-glutamyl transpeptidase/Alfa-fetoprotein], FIB4, fibrosis index, cirrhosis discriminate score, and Fibro-quotient were calculated, and the diagnostic accuracies of all of the fibrosis indices were compared between the F0-2 (no-mild fibrosis) and F3-6 (significant fibrosis) groups. Results: All of the noninvasive markers were significantly correlated with the stage of liver fibrosis (p < 0,001). To predict significant fibrosis (F ≥ 3), the area under the curve (95% CI) was found to be greatest for APGA (0.83 [0.74-0.86]), followed by FIB-4 (0.75[0.69-0.80]), the globulin/platelet model (0.74 [0.68-0.79]), fibrosis index (0.72 [0.6-0.78], cirrhosis discriminate score (0.71 [0.64-0.76]) and Fibro-quotient (0.62 [0.55-0.7]). The area under the receiver operating characteristic curves of APGA was significantly higher than that of the other noninvasive fibrosis markers (p < 0.05). Conclusions: While the APGA index was found to be the most valuable test for the prediction significant fibrosis in patients with chronic hepatitis B, GP model was the thirth valuable test. Therefore, we recommended that APGA could be used instead of the GP model for prediction liver fibrosis.
topic Chronic hepatitis B
Liver fibrosis
Noninvasive fibrosis marker
Globulin/platelet model
url http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082015001200004&lng=en&tlng=en
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