Assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adults

Background Heart rate variability (HRV) is a psycho-physiological phenomenon with broad health implications. Different data analysis methods have been used to assess the autonomic nervous system activity, but the validation of new indexes that accurately describe its balance through non-invasive met...

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Main Authors: Gines Navarro-Lomas, Alejandro De-la-O, Lucas Jurado-Fasoli, Manuel J. Castillo, Pedro Femia, Francisco J. Amaro-Gahete
Format: Article
Language:English
Published: PeerJ Inc. 2020-11-01
Series:PeerJ
Subjects:
HRV
Online Access:https://peerj.com/articles/10178.pdf
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spelling doaj-b16bb7127c1d4157bcf38b6f3053216e2020-11-25T04:00:59ZengPeerJ Inc.PeerJ2167-83592020-11-018e1017810.7717/peerj.10178Assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adultsGines Navarro-Lomas0Alejandro De-la-O1Lucas Jurado-Fasoli2Manuel J. Castillo3Pedro Femia4Francisco J. Amaro-Gahete5EFFECTS-262 Research Group, Department of Physiology, University of Granada, Granada, SpainEFFECTS-262 Research Group, Department of Physiology, University of Granada, Granada, SpainEFFECTS-262 Research Group, Department of Physiology, University of Granada, Granada, SpainEFFECTS-262 Research Group, Department of Physiology, University of Granada, Granada, SpainDepartment of Statistics, University of Granada, Granada, SpainEFFECTS-262 Research Group, Department of Physiology, University of Granada, Granada, SpainBackground Heart rate variability (HRV) is a psycho-physiological phenomenon with broad health implications. Different data analysis methods have been used to assess the autonomic nervous system activity, but the validation of new indexes that accurately describe its balance through non-invasive methods (i.e., HRV analysis) is of clinical interest. This study aimed: (i) to evaluate the association of the Stress Score (SS) and the Sympathetic/Parasympathetic Ratio (S/PS) with time domain and frequency domain analysis of HRV, and (ii) to set reference values of SS and S/PS in sedentary healthy adults. Methods A total of 156 sedentary healthy adults (38.4 ± 15.57 years old, 81 women), aged were involved in this study. HRV was measured for 15 min in a supine position at rest. SS and S/PS were calculated from the non-linear HRV analyses based on Poincare Plot. Results Stress Score showed a non-linear negative power-law relationship with SDNN (β = −0.969; R2 = 0.963; P < 0.001), RMSSD (β = −0.867; R2 = 0.722; P < 0.001), high frequency (β = −0.834; R2 = 0.752; P =< 0.001), low frequency (β = −0.627; R2 = 0.330; P < 0.001), SD1 (β = −0.867; R2 = 0.722; P < 0.001) and SD2 (β = −1.000; R2 > 0.999; P < 0.001). There was observed a negative cubic relationship between SS with PNN50 (β = −1.972; R2 = 0.644; P < 0.001). A linear regression model was conducted between SS with Ratio Low/High Frequency (β = 0.026; R2 < 0.001; P = 0.750). Non-linear power-law regression models were built between S/PS and SDNN (β = −0.990; R2 = 0.981; P < 0.001), RMSSD (β = −0.973; R2 = 0.939; P < 0.001), high frequency (β = −0.928; R2 = 0.970; P < 0.001), low frequency (β = −2.344; R2 = 0.557; P < 0.001), SD1 (β = −0.973; R2 = 0.939; P < 0.001) and SD2 (β = −0.611; R2 = 0.908; P < 0.001). A non-linear negative regression model was built between S/PS and PNN50 (β = −3.412; R2 = 0.868; P < 0.001). A linear regression model was conducted between S/PS and SD2/SD1 (β = 0.075; R2 = 0.006; P < 0.001). Conclusion Our results support the use of SS as a sympathetic activity marker, and S/PS as an indicator of the sympathetic and parasympathetic activity of the autonomic nervous system in sedentary healthy adults.https://peerj.com/articles/10178.pdfHRVStress scoreSympathetic/parasympathetic ratioKubiosPoincare plot
collection DOAJ
language English
format Article
sources DOAJ
author Gines Navarro-Lomas
Alejandro De-la-O
Lucas Jurado-Fasoli
Manuel J. Castillo
Pedro Femia
Francisco J. Amaro-Gahete
spellingShingle Gines Navarro-Lomas
Alejandro De-la-O
Lucas Jurado-Fasoli
Manuel J. Castillo
Pedro Femia
Francisco J. Amaro-Gahete
Assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adults
PeerJ
HRV
Stress score
Sympathetic/parasympathetic ratio
Kubios
Poincare plot
author_facet Gines Navarro-Lomas
Alejandro De-la-O
Lucas Jurado-Fasoli
Manuel J. Castillo
Pedro Femia
Francisco J. Amaro-Gahete
author_sort Gines Navarro-Lomas
title Assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adults
title_short Assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adults
title_full Assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adults
title_fullStr Assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adults
title_full_unstemmed Assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adults
title_sort assessment of autonomous nerve system through non-linear heart rate variability outcomes in sedentary healthy adults
publisher PeerJ Inc.
series PeerJ
issn 2167-8359
publishDate 2020-11-01
description Background Heart rate variability (HRV) is a psycho-physiological phenomenon with broad health implications. Different data analysis methods have been used to assess the autonomic nervous system activity, but the validation of new indexes that accurately describe its balance through non-invasive methods (i.e., HRV analysis) is of clinical interest. This study aimed: (i) to evaluate the association of the Stress Score (SS) and the Sympathetic/Parasympathetic Ratio (S/PS) with time domain and frequency domain analysis of HRV, and (ii) to set reference values of SS and S/PS in sedentary healthy adults. Methods A total of 156 sedentary healthy adults (38.4 ± 15.57 years old, 81 women), aged were involved in this study. HRV was measured for 15 min in a supine position at rest. SS and S/PS were calculated from the non-linear HRV analyses based on Poincare Plot. Results Stress Score showed a non-linear negative power-law relationship with SDNN (β = −0.969; R2 = 0.963; P < 0.001), RMSSD (β = −0.867; R2 = 0.722; P < 0.001), high frequency (β = −0.834; R2 = 0.752; P =< 0.001), low frequency (β = −0.627; R2 = 0.330; P < 0.001), SD1 (β = −0.867; R2 = 0.722; P < 0.001) and SD2 (β = −1.000; R2 > 0.999; P < 0.001). There was observed a negative cubic relationship between SS with PNN50 (β = −1.972; R2 = 0.644; P < 0.001). A linear regression model was conducted between SS with Ratio Low/High Frequency (β = 0.026; R2 < 0.001; P = 0.750). Non-linear power-law regression models were built between S/PS and SDNN (β = −0.990; R2 = 0.981; P < 0.001), RMSSD (β = −0.973; R2 = 0.939; P < 0.001), high frequency (β = −0.928; R2 = 0.970; P < 0.001), low frequency (β = −2.344; R2 = 0.557; P < 0.001), SD1 (β = −0.973; R2 = 0.939; P < 0.001) and SD2 (β = −0.611; R2 = 0.908; P < 0.001). A non-linear negative regression model was built between S/PS and PNN50 (β = −3.412; R2 = 0.868; P < 0.001). A linear regression model was conducted between S/PS and SD2/SD1 (β = 0.075; R2 = 0.006; P < 0.001). Conclusion Our results support the use of SS as a sympathetic activity marker, and S/PS as an indicator of the sympathetic and parasympathetic activity of the autonomic nervous system in sedentary healthy adults.
topic HRV
Stress score
Sympathetic/parasympathetic ratio
Kubios
Poincare plot
url https://peerj.com/articles/10178.pdf
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