A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets.

The first pandemic of the 21(st) century, pandemic H1N1 2009 (pH1N1 2009), emerged from a swine-origin source. Although human infections with swine-origin influenza have been reported previously, none went on to cause a pandemic or indeed any sustained human transmission. In previous pandemics, spec...

Full description

Bibliographic Details
Main Authors: Neeltje van Doremalen, Holly Shelton, Kim L Roberts, Ian M Jones, Ray J Pickles, Catherine I Thompson, Wendy S Barclay
Format: Article
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3187803?pdf=render