SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS

SALMON SOFT ROE DNA ON BLOOD CELLS SECRETION OF CYTOKINES IN HEALTHY DONORS

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<strong>Abstract. </strong>Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is est...

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Bibliographic Details
Main Author: L. N. Fedjanina
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
salmon soft roe DNA
cytokines
healthy donors
lymphocytes
lymphocytes subpopulations
Online Access:http://mimmun.ru/index.php/mimmun/article/view/654
Description
Summary:<strong>Abstract. </strong>Salmon soft roe DNA influence on healthy donors blood cells secretion of early hemopoietic factors (IL-3, GM-CSF, TNFα) as well as biologically active substance influence on cytokine balance of Тh1 and Тh2 responses (IFNγ, IL-10) in vitro was studied. It is established, that DNA has modulatory effect on secretion of all investigated cytokines - IL-3, GM-CSF, TNFα, INFγ and IL-10 by blood cells of healthy donors, increases their initially low concentration, reduces initially high and does not have essential influence at an average level of their secretion. Under action of DNA IFNγ level (stimulation index=3,3) increases more significantly than IL-10 level (stimulation index =1,9). Thus, salmon soft roe DNA possesses immunomodulatory properties.
ISSN:1563-0625
2313-741X

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