Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review

Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review

Abstract Background In non-inferiority trials, there is a concern that intention-to-treat (ITT) analysis, by including participants who did not receive the planned interventions, may bias towards making the treatment and control arms look similar and lead to mistaken claims of non-inferiority. In co...

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Bibliographic Details
Main Authors: Anthony D. Bai, Adam S. Komorowski, Carson K. L. Lo, Pranav Tandon, Xena X. Li, Vaibhav Mokashi, Anna Cvetkovic, Aidan Findlater, Laurel Liang, George Tomlinson, Mark Loeb, Dominik Mertz, for the McMaster Infectious Diseases Fellow Research Group
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Medical Research Methodology
Subjects:
Non-inferiority trials
Intention-to-treat
Per protocol
Systematic review
Online Access:https://doi.org/10.1186/s12874-021-01260-7

Internet

https://doi.org/10.1186/s12874-021-01260-7

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