Revealing Adenosine A<sub>2A</sub>-Dopamine D<sub>2</sub> Receptor Heteromers in Parkinson’s Disease Post-Mortem Brain through a New AlphaScreen-Based Assay

Revealing Adenosine A<sub>2A</sub>-Dopamine D<sub>2</sub> Receptor Heteromers in Parkinson’s Disease Post-Mortem Brain through a New AlphaScreen-Based Assay

<b>Background</b>: Several biophysical techniques have been successfully implemented to detect G protein-coupled receptors (GPCRs) heteromerization. Although these approaches have made it possible to ascertain the presence of GPCR heteromers in animal models of disease, no success has be...

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Bibliographic Details
Main Authors: Víctor Fernández-Dueñas, Maricel Gómez-Soler, Marta Valle-León, Masahiko Watanabe, Isidre Ferrer, Francisco Ciruela
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
AlphaScreen
GPCR oligomerization
Parkinson’s disease
Adenosine A<sub>2A</sub> receptor
Dopamine D<sub>2</sub> receptor
Online Access:https://www.mdpi.com/1422-0067/20/14/3600

Internet

https://www.mdpi.com/1422-0067/20/14/3600

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