PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
Objective: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1. PGC-1α expression in the liver is highly elevated in obese and diabetic conditions, leading to increased hepatic glucose production. We previously s...
Main Authors: | Jaemin Lee, Mario Andrés Salazar Hernández, Thomas Auen, Patrick Mucka, Justin Lee, Umut Ozcan |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2018-01-01
|
Series: | Molecular Metabolism |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877817307378 |
Similar Items
-
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.
by: Justin R Hassler, et al.
Published: (2015-10-01) -
Abnormal Glucose Metabolism and Insulin Resistance Are Induced via the IRE1α/XBP-1 Pathway in Subclinical Hypothyroidism
by: Chao Xu, et al.
Published: (2019-05-01) -
The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity
by: Yoon Mi Cho, et al.
Published: (2018-08-01) -
Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism
by: Hee-Jin Jun, et al.
Published: (2012-01-01) -
PCAF Improves Glucose Homeostasis by Suppressing the Gluconeogenic Activity of PGC-1α
by: Cheng Sun, et al.
Published: (2014-12-01)