Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival

Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival

Circulating extracellular vesicles (EVs) are recognized as biomarkers and effectors of endothelial dysfunction, the initiating step of cardiovascular abnormalities. Among these EVs, microparticles (MPs) are vesicles directly released from the cytoplasmic membrane of activated cells. MPs were shown t...

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Bibliographic Details
Main Authors: Aisha Osman, Heba El-Gamal, Mazhar Pasha, Asad Zeidan, Hesham M. Korashy, Shahenda S. Abdelsalam, Maram Hasan, Tarek Benameur, Abdelali Agouni
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
extracellular vesicles (EVs)
microparticles (MPs)
endothelial function (dysfunction)
apoptosis
cardiovascular disease
ER stress
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.584791/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2020.584791/full

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