A self-sustaining nanoplatform overcomes TRAIL-resistance of pancreatic cancer by a source-broadening and expenditure-reducing apoptosis strategy

A self-sustaining nanoplatform overcomes TRAIL-resistance of pancreatic cancer by a source-broadening and expenditure-reducing apoptosis strategy

Pancreatic cancer generates resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by downregulating death receptors and switching pro-apoptosis to anti-apoptosis through caspases blockers like X-linked inhibitor of apoptosis proteins (XIAPs) and survivin. From this perspectiv...

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Bibliographic Details
Main Authors: Xianzhou Huang, Haijun Li, Chunqing Ou, Yaqian Shu, Rui Luo, Xinchao Li, Shouchun Chen, Qinjie Wu, Changyang Gong, Lei Liu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Materials & Design
Subjects:
R6ST
Celecoxib
Death receptors
Nanoplatform
Surviving
XIAP
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127521006924

Internet

http://www.sciencedirect.com/science/article/pii/S0264127521006924

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