Aβ-induced vulnerability propagates via the brain’s default mode network

Aβ-induced vulnerability propagates via the brain’s default mode network

Amyloid-β (Aβ) deposition occurs in Alzheimer's disease but its relation to disease features such as local brain hypometabolism or cognitive decline is unclear. Here, the authors show that Aβ aggregation in the brain’s default mode network leads to hypometabolism in distant but functionally con...

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Bibliographic Details
Main Authors: Tharick A. Pascoal, Sulantha Mathotaarachchi, Min Su Kang, Sara Mohaddes, Monica Shin, Ah Yeon Park, Maxime J. Parent, Andrea L. Benedet, Mira Chamoun, Joseph Therriault, Heungsun Hwang, A. Claudio Cuello, Bratislav Misic, Jean-Paul Soucy, John A. D. Aston, Serge Gauthier, Pedro Rosa-Neto
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10217-w

Internet

https://doi.org/10.1038/s41467-019-10217-w

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