Retinal miRNA Functions in Health and Disease
The health and function of our visual system relies on accurate gene expression. While many genetic mutations are associated with visual impairment and blindness, we are just beginning to understand the complex interplay between gene regulation and retinal pathologies. MicroRNAs (miRNAs), a class of...
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2019-05-01
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doaj-b3bbce1a58d24812bde06962f8f4fea72020-11-25T02:08:00ZengMDPI AGGenes2073-44252019-05-0110537710.3390/genes10050377genes10050377Retinal miRNA Functions in Health and DiseaseMarta Zuzic0Jesus Eduardo Rojo Arias1Stefanie Gabriele Wohl2Volker Busskamp3Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, GermanyCenter for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Biological and Vision Sciences, The State University of New York, College of Optometry, New York, NY 10036, USACenter for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, 01307 Dresden, GermanyThe health and function of our visual system relies on accurate gene expression. While many genetic mutations are associated with visual impairment and blindness, we are just beginning to understand the complex interplay between gene regulation and retinal pathologies. MicroRNAs (miRNAs), a class of non-coding RNAs, are important regulators of gene expression that exert their function through post-transcriptional silencing of complementary mRNA targets. According to recent transcriptomic analyses, certain miRNA species are expressed in all retinal cell types, while others are cell type-specific. As miRNAs play important roles in homeostasis, cellular function, and survival of differentiated retinal cell types, their dysregulation is associated with retinal degenerative diseases. Thus, advancing our understanding of the genetic networks modulated by miRNAs is central to harnessing their potential as therapeutic agents to overcome visual impairment. In this review, we summarize the role of distinct miRNAs in specific retinal cell types, the current knowledge on their implication in inherited retinal disorders, and their potential as therapeutic agents.https://www.mdpi.com/2073-4425/10/5/377microRNAretinaphotoreceptorsrodsconesbipolar cellsMüller gliaretinal inherited disordersretinitis pigmentosaretinal degeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Zuzic Jesus Eduardo Rojo Arias Stefanie Gabriele Wohl Volker Busskamp |
spellingShingle |
Marta Zuzic Jesus Eduardo Rojo Arias Stefanie Gabriele Wohl Volker Busskamp Retinal miRNA Functions in Health and Disease Genes microRNA retina photoreceptors rods cones bipolar cells Müller glia retinal inherited disorders retinitis pigmentosa retinal degeneration |
author_facet |
Marta Zuzic Jesus Eduardo Rojo Arias Stefanie Gabriele Wohl Volker Busskamp |
author_sort |
Marta Zuzic |
title |
Retinal miRNA Functions in Health and Disease |
title_short |
Retinal miRNA Functions in Health and Disease |
title_full |
Retinal miRNA Functions in Health and Disease |
title_fullStr |
Retinal miRNA Functions in Health and Disease |
title_full_unstemmed |
Retinal miRNA Functions in Health and Disease |
title_sort |
retinal mirna functions in health and disease |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2019-05-01 |
description |
The health and function of our visual system relies on accurate gene expression. While many genetic mutations are associated with visual impairment and blindness, we are just beginning to understand the complex interplay between gene regulation and retinal pathologies. MicroRNAs (miRNAs), a class of non-coding RNAs, are important regulators of gene expression that exert their function through post-transcriptional silencing of complementary mRNA targets. According to recent transcriptomic analyses, certain miRNA species are expressed in all retinal cell types, while others are cell type-specific. As miRNAs play important roles in homeostasis, cellular function, and survival of differentiated retinal cell types, their dysregulation is associated with retinal degenerative diseases. Thus, advancing our understanding of the genetic networks modulated by miRNAs is central to harnessing their potential as therapeutic agents to overcome visual impairment. In this review, we summarize the role of distinct miRNAs in specific retinal cell types, the current knowledge on their implication in inherited retinal disorders, and their potential as therapeutic agents. |
topic |
microRNA retina photoreceptors rods cones bipolar cells Müller glia retinal inherited disorders retinitis pigmentosa retinal degeneration |
url |
https://www.mdpi.com/2073-4425/10/5/377 |
work_keys_str_mv |
AT martazuzic retinalmirnafunctionsinhealthanddisease AT jesuseduardorojoarias retinalmirnafunctionsinhealthanddisease AT stefaniegabrielewohl retinalmirnafunctionsinhealthanddisease AT volkerbusskamp retinalmirnafunctionsinhealthanddisease |
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