Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs
Osteoporosis is a systemic bone disease with an increasing prevalence in the elderly population. There is conflicting opinion about whether osteoporosis affects the alveolar bone of the jaws and whether it poses a risk to the osseointegration of dental implants. The aim of the present study was to e...
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doaj-b3cb9d99892845d9bcb4a49529f171102020-11-24T23:11:57ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-06-01810.3389/fphys.2017.00426267102Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in MinipigsMatthias C. Schulz0Jan Kowald1Jan Kowald2Sven Estenfelder3Sven Estenfelder4Roland Jung5Eberhard Kuhlisch6Uwe Eckelt7Ronald Mai8Lorenz C. Hofbauer9Christian Stroszczynski10Bernd Stadlinger11Department of Oral and Maxillofacial Surgery, Medical Faculty “Carl Gustav Carus,” Technische Universität DresdenDresden, GermanyDepartment of Radiology, Medical Faculty “Carl Gustav Carus,” Technische Universität DresdenDresden, GermanyDivision of Nephrology, Department of Internal Medicine III, Medical Faculty “Carl Gustav Carus,” Technische Universität DresdenDresden, GermanyDepartment of Radiology, Medical Faculty “Carl Gustav Carus,” Technische Universität DresdenDresden, GermanyDepartment of Internal Medicine III, University of UlmUlm, GermanyExperimental Center, Medical Faculty “Carl Gustav Carus,” Technische Universität DresdenDresden, GermanyInstitute for Medical Informatics and Biometry, Medical Faculty “Carl Gustav Carus,” Technische Universität DresdenDresden, GermanyDepartment of Oral and Maxillofacial Surgery, Medical Faculty “Carl Gustav Carus,” Technische Universität DresdenDresden, GermanyDepartment of Oral and Maxillofacial Surgery, Medical Faculty “Carl Gustav Carus,” Technische Universität DresdenDresden, GermanyDivision of Endocrinology, Diabetes and Bone Diseases, Department of Medicine III, Medical Faculty “Carl Gustav Carus,” Technische Universität DresdenDresden, GermanyDepartment of Radiology, University Hospital RegensburgRegensburg, GermanyClinic of Cranio-Maxillofacial and Oral Surgery, University of Zurich, University Hospital ZurichZurich, SwitzerlandOsteoporosis is a systemic bone disease with an increasing prevalence in the elderly population. There is conflicting opinion about whether osteoporosis affects the alveolar bone of the jaws and whether it poses a risk to the osseointegration of dental implants. The aim of the present study was to evaluate the effects of systemic glucocorticoid administration on the jaw bone density of minipigs. Thirty-seven adult female minipigs were randomly divided into two groups. Quantitative computed tomography (QCT) was used to assess bone mineral density BMD of the lumbar spine as well as the mandible and maxilla, and blood was drawn. One group of minipigs initially received 1.0 mg prednisolone per kg body weight daily for 2 months. The dose was tapered to 0.5 mg per kg body weight per day thereafter. The animals in the other group served as controls and received placebo. QCT and blood analysis were repeated after 6 and 9 months. BMD was compared between the two groups by measuring Hounsfield units, and serum levels of several bone metabolic markers were also assessed. A decrease in BMD was observed in the jaws from baseline to 9 months. This was more pronounced in the prednisolone group. Statistically significant differences were reached for the mandible (p < 0.001) and the maxilla (p < 0.001). The administration of glucocorticoids reduced the BMD in the jaws of minipigs. The described model shows promise in the evaluation of osseointegration of dental implants in bone that is compromised by osteoporosis.http://journal.frontiersin.org/article/10.3389/fphys.2017.00426/fullanimal modelsbonebone mineralizationoral cavityosteoporosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthias C. Schulz Jan Kowald Jan Kowald Sven Estenfelder Sven Estenfelder Roland Jung Eberhard Kuhlisch Uwe Eckelt Ronald Mai Lorenz C. Hofbauer Christian Stroszczynski Bernd Stadlinger |
spellingShingle |
Matthias C. Schulz Jan Kowald Jan Kowald Sven Estenfelder Sven Estenfelder Roland Jung Eberhard Kuhlisch Uwe Eckelt Ronald Mai Lorenz C. Hofbauer Christian Stroszczynski Bernd Stadlinger Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs Frontiers in Physiology animal models bone bone mineralization oral cavity osteoporosis |
author_facet |
Matthias C. Schulz Jan Kowald Jan Kowald Sven Estenfelder Sven Estenfelder Roland Jung Eberhard Kuhlisch Uwe Eckelt Ronald Mai Lorenz C. Hofbauer Christian Stroszczynski Bernd Stadlinger |
author_sort |
Matthias C. Schulz |
title |
Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs |
title_short |
Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs |
title_full |
Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs |
title_fullStr |
Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs |
title_full_unstemmed |
Site-Specific Variations in Bone Mineral Density under Systemic Conditions Inducing Osteoporosis in Minipigs |
title_sort |
site-specific variations in bone mineral density under systemic conditions inducing osteoporosis in minipigs |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2017-06-01 |
description |
Osteoporosis is a systemic bone disease with an increasing prevalence in the elderly population. There is conflicting opinion about whether osteoporosis affects the alveolar bone of the jaws and whether it poses a risk to the osseointegration of dental implants. The aim of the present study was to evaluate the effects of systemic glucocorticoid administration on the jaw bone density of minipigs. Thirty-seven adult female minipigs were randomly divided into two groups. Quantitative computed tomography (QCT) was used to assess bone mineral density BMD of the lumbar spine as well as the mandible and maxilla, and blood was drawn. One group of minipigs initially received 1.0 mg prednisolone per kg body weight daily for 2 months. The dose was tapered to 0.5 mg per kg body weight per day thereafter. The animals in the other group served as controls and received placebo. QCT and blood analysis were repeated after 6 and 9 months. BMD was compared between the two groups by measuring Hounsfield units, and serum levels of several bone metabolic markers were also assessed. A decrease in BMD was observed in the jaws from baseline to 9 months. This was more pronounced in the prednisolone group. Statistically significant differences were reached for the mandible (p < 0.001) and the maxilla (p < 0.001). The administration of glucocorticoids reduced the BMD in the jaws of minipigs. The described model shows promise in the evaluation of osseointegration of dental implants in bone that is compromised by osteoporosis. |
topic |
animal models bone bone mineralization oral cavity osteoporosis |
url |
http://journal.frontiersin.org/article/10.3389/fphys.2017.00426/full |
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