The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses

The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored. Here, we show the involvement of a small GTPase, RAB2B, and its effector protein, Golgi-associated...

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Bibliographic Details
Main Authors: Michihiro Takahama, Mitsunori Fukuda, Norihiko Ohbayashi, Tatsuya Kozaki, Takuma Misawa, Toru Okamoto, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
host defense
innate immunity
antiviral response
interferon
Rab GTPase
organelle
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312275

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http://www.sciencedirect.com/science/article/pii/S2211124717312275

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