Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer

Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer

Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with in silico, in vitro and in vivo approaches.Methods: Computational drug reposit...

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Bibliographic Details
Main Authors: Hanne-Line Rabben, Gøran Troseth Andersen, Aleksandr Ianevski, Magnus Kringstad Olsen, Denis Kainov, Jon Erik Grønbech, Timothy Cragin Wang, Duan Chen, Chun-Mei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
gastric cancer
ivermectin
drug repositioning
ingenuity pathway analysis
in silico
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.625991/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.625991/full

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