Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity

Identification of danthron as an isoform-specific inhibitor of HEME OXYGENASE-1/cytochrome P450 reductase interaction with anti-tumor activity

Abstract Background Heme oxygenase (HO) catalyzes NADPH-dependent degradation of heme to liberate iron, carbon monoxide and biliverdin. The interaction between HO and cytochrome P450 reductase (CPR), an electron donor, is essential for HO activity. HO-1 is a stress-inducible isoform whereas HO-2 is...

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Bibliographic Details
Main Authors: Yi-Tai Chou, Fu-Fei Hsu, Dun-Yao Hu, Ying-Chih Chen, Yuan-Hao Hsu, John T.-A. Hsu, Lee-Young Chau
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Biomedical Science
Subjects:
Heme oxygenase-1
Cytochrome P450 reductase
Protein-protein interaction
Anti-cancer drug
Online Access:http://link.springer.com/article/10.1186/s12929-018-0411-y

Internet

http://link.springer.com/article/10.1186/s12929-018-0411-y

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