Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people

Jakob Jäger,1,2 Cornel Christian Sieber,1,3 Karl-Günter Gaßmann,1,2 Martin Ritt1,2 1Institute for Biomedicine of Ageing (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), D-90408 Nürnberg, Germany; 2Department of Internal Medicine...

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Main Authors: Jäger J, Sieber CC, Gaßmann KG, Ritt M
Format: Article
Language:English
Published: Dove Medical Press 2019-02-01
Series:Clinical Interventions in Aging
Subjects:
Online Access:https://www.dovepress.com/changes-of-a-frailty-index-based-on-common-blood-and-urine-tests-durin-peer-reviewed-article-CIA
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spelling doaj-b464d04655a0409ebe1f8fbfe8de8b8c2020-11-24T23:09:39ZengDove Medical PressClinical Interventions in Aging1178-19982019-02-01Volume 1447348444291Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older peopleJäger JSieber CCGaßmann KGRitt MJakob Jäger,1,2 Cornel Christian Sieber,1,3 Karl-Günter Gaßmann,1,2 Martin Ritt1,2 1Institute for Biomedicine of Ageing (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), D-90408 Nürnberg, Germany; 2Department of Internal Medicine III (Medicine of Ageing), Geriatrics Center Erlangen, Malteser Hospital Erlangen, D-91054 Erlangen, Germany; 3Department of General Internal Medicine and Geriatrics, Hospital of the Order of St John of God, D-93049 Regensburg, Germany Background: We aimed to evaluate the abilities of a 21-item frailty index based on laboratory blood and urine tests (FI-Lab21) assessed at different points in time, ie, at admission to hospital (FI-Lab21admission) and before discharge from hospital (FI-Lab21discharge), and the change of the FI-Lab21 during the hospital stay to predict 6-month and 1-year mortality in hospitalized geriatric patients. Methods: Five hundred hospitalized geriatric patients aged ≥65 years were included in this analysis. Follow-up data were acquired after a period of 6 months and 1 year. Results: The FI-Lab21admission and FI-Lab21discharge scores were 0.33±0.15 and 0.31±0.14, respectively (P<0.001). The FI-Lab21admission and FI-Lab21discharge both predicted 6-month and 1-year mortality (areas under the receiver operating characteristic curves: 0.72, 0.72, 0.77, and 0.75, respectively, all P<0.001). The predictive abilities for 6-month and 1-year mortality of the FI-Lab21admission were inferior compared with those of the FI-Lab21discharge (all P<0.05). Patients with a reduction in or stable FI-Lab21 score during the hospital stay revealed lower 6-month and 1-year mortality rates compared with the persons whose FI-Lab21 score increased during the hospital stay (all P<0.05). After adjustment for age, sex, and FI-Lab21admission, each 1% decrease in the FI-Lab21 during the hospital stay was associated with a decrease in 6-month and 1-year mortality of 5.9% and 5.3% (both P<0.001), respectively. Conclusion: The FI-Lab21 assessed at admission or discharge and the changes of the FI-Lab21 during the hospital stay emerged as interesting and feasible approaches to stratify mortality risk in hospitalized geriatric patients. Keywords: geriatric wards, frailty, frailty index, cumulative deficit, older peoplehttps://www.dovepress.com/changes-of-a-frailty-index-based-on-common-blood-and-urine-tests-durin-peer-reviewed-article-CIAgeriatric wardsfrailtyfrailty indexcumulative deficitolder people
collection DOAJ
language English
format Article
sources DOAJ
author Jäger J
Sieber CC
Gaßmann KG
Ritt M
spellingShingle Jäger J
Sieber CC
Gaßmann KG
Ritt M
Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people
Clinical Interventions in Aging
geriatric wards
frailty
frailty index
cumulative deficit
older people
author_facet Jäger J
Sieber CC
Gaßmann KG
Ritt M
author_sort Jäger J
title Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people
title_short Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people
title_full Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people
title_fullStr Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people
title_full_unstemmed Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people
title_sort changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people
publisher Dove Medical Press
series Clinical Interventions in Aging
issn 1178-1998
publishDate 2019-02-01
description Jakob Jäger,1,2 Cornel Christian Sieber,1,3 Karl-Günter Gaßmann,1,2 Martin Ritt1,2 1Institute for Biomedicine of Ageing (IBA), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), D-90408 Nürnberg, Germany; 2Department of Internal Medicine III (Medicine of Ageing), Geriatrics Center Erlangen, Malteser Hospital Erlangen, D-91054 Erlangen, Germany; 3Department of General Internal Medicine and Geriatrics, Hospital of the Order of St John of God, D-93049 Regensburg, Germany Background: We aimed to evaluate the abilities of a 21-item frailty index based on laboratory blood and urine tests (FI-Lab21) assessed at different points in time, ie, at admission to hospital (FI-Lab21admission) and before discharge from hospital (FI-Lab21discharge), and the change of the FI-Lab21 during the hospital stay to predict 6-month and 1-year mortality in hospitalized geriatric patients. Methods: Five hundred hospitalized geriatric patients aged ≥65 years were included in this analysis. Follow-up data were acquired after a period of 6 months and 1 year. Results: The FI-Lab21admission and FI-Lab21discharge scores were 0.33±0.15 and 0.31±0.14, respectively (P<0.001). The FI-Lab21admission and FI-Lab21discharge both predicted 6-month and 1-year mortality (areas under the receiver operating characteristic curves: 0.72, 0.72, 0.77, and 0.75, respectively, all P<0.001). The predictive abilities for 6-month and 1-year mortality of the FI-Lab21admission were inferior compared with those of the FI-Lab21discharge (all P<0.05). Patients with a reduction in or stable FI-Lab21 score during the hospital stay revealed lower 6-month and 1-year mortality rates compared with the persons whose FI-Lab21 score increased during the hospital stay (all P<0.05). After adjustment for age, sex, and FI-Lab21admission, each 1% decrease in the FI-Lab21 during the hospital stay was associated with a decrease in 6-month and 1-year mortality of 5.9% and 5.3% (both P<0.001), respectively. Conclusion: The FI-Lab21 assessed at admission or discharge and the changes of the FI-Lab21 during the hospital stay emerged as interesting and feasible approaches to stratify mortality risk in hospitalized geriatric patients. Keywords: geriatric wards, frailty, frailty index, cumulative deficit, older people
topic geriatric wards
frailty
frailty index
cumulative deficit
older people
url https://www.dovepress.com/changes-of-a-frailty-index-based-on-common-blood-and-urine-tests-durin-peer-reviewed-article-CIA
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