Aspects of the Sinonasal Sarcoidosis Manifestations in Iran
Introduction: Sinonasal Sarcoidosis (SNS) is the most common involvement of upper respiratory tract sarcoidosis disease. Not much data is available on the detailed diagnostic aspects of Iranian sinonasal sarcoidosis patients. Aim: The current study is the first report from Iran that evaluates the pr...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2018-10-01
|
Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/12144/36637_CE[Ra1]_F(SL)_PF1(SJ_SL)_PF1(SJ_SHU)_PN(P).pdf |
id |
doaj-b4965fcc9bc54cd789b5a174cf7aa78c |
---|---|
record_format |
Article |
spelling |
doaj-b4965fcc9bc54cd789b5a174cf7aa78c2020-11-25T03:31:50ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-10-011210OC17OC2110.7860/JCDR/2018/36637.12144Aspects of the Sinonasal Sarcoidosis Manifestations in IranAli Safavi Naeini0Arda Kiani1Shapoor Safari2Jahangir Ghorbani3Kimia Taghavi4Mojganmotevally Bashi5Mehdi Kazempour-Dizaji6Atefeh Abedini7Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.Introduction: Sinonasal Sarcoidosis (SNS) is the most common involvement of upper respiratory tract sarcoidosis disease. Not much data is available on the detailed diagnostic aspects of Iranian sinonasal sarcoidosis patients. Aim: The current study is the first report from Iran that evaluates the prevalence and describes the clinical features of patients with sinonasal sarcoidosis in Iran. Materials and Methods: This cross-sectional descriptive study was performed on the eighty eight newly diagnosed and biopsy proven sarcoidosis patients who were suspected to have head and neck disorders. Sinonasal involvement of sarcoidosis was examined via Computed Tomography of Para-nasal Sinuses (CT PNS) imaging as well as rhinoscopy, and histopathologic examinations on the nasal or sinusitis mucosa biopsy sample. Data were analysed by Statistical Package for Social Sciences (SPSS) and differences between two groups were obtained using the χ2 test, the Mann-Whitney test and independent t-test with consideration of a statistically significant p-value of <0.05. Results: Sinonasal disorders were observed in 32 patients. Association of sinonasal and pulmonary sarcoidosis were confirmed in 18 of 32 SNS patients (56.25%). Rhinoscopy investigations demonstrated that the prevalent presenting signs were nasal crusting in 4 patients (14.3%), septal perforation in 3 patients (8.6%), mucosal hypertrophy in 9 patients (28.6%), synechia in 2 patients (5.7%), middle turbinate hypertrophy in 4 patients (11.4%) and submucosal nodule in 10 patients (31.4%). Conclusion: Endoscopic investigations indicated that the most frequent manifestation of SNS cases was inflammatory rhinosinusitis often with nodular lesions on the septum and turbinates. Further studies with bigger sample size are recommended in order to measure the sensitivity and specificity of nasal obstruction as a diagnostic parameter of sinonasal sarcoidosis patients of Iran.https://jcdr.net/articles/PDF/12144/36637_CE[Ra1]_F(SL)_PF1(SJ_SL)_PF1(SJ_SHU)_PN(P).pdferythema nodosumgranulomamethotrexatepulmonarysinusitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ali Safavi Naeini Arda Kiani Shapoor Safari Jahangir Ghorbani Kimia Taghavi Mojganmotevally Bashi Mehdi Kazempour-Dizaji Atefeh Abedini |
spellingShingle |
Ali Safavi Naeini Arda Kiani Shapoor Safari Jahangir Ghorbani Kimia Taghavi Mojganmotevally Bashi Mehdi Kazempour-Dizaji Atefeh Abedini Aspects of the Sinonasal Sarcoidosis Manifestations in Iran Journal of Clinical and Diagnostic Research erythema nodosum granuloma methotrexate pulmonary sinusitis |
author_facet |
Ali Safavi Naeini Arda Kiani Shapoor Safari Jahangir Ghorbani Kimia Taghavi Mojganmotevally Bashi Mehdi Kazempour-Dizaji Atefeh Abedini |
author_sort |
Ali Safavi Naeini |
title |
Aspects of the Sinonasal Sarcoidosis Manifestations in Iran |
title_short |
Aspects of the Sinonasal Sarcoidosis Manifestations in Iran |
title_full |
Aspects of the Sinonasal Sarcoidosis Manifestations in Iran |
title_fullStr |
Aspects of the Sinonasal Sarcoidosis Manifestations in Iran |
title_full_unstemmed |
Aspects of the Sinonasal Sarcoidosis Manifestations in Iran |
title_sort |
aspects of the sinonasal sarcoidosis manifestations in iran |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2018-10-01 |
description |
Introduction: Sinonasal Sarcoidosis (SNS) is the most common involvement of upper respiratory tract sarcoidosis disease. Not much data is available on the detailed diagnostic aspects of Iranian sinonasal sarcoidosis patients. Aim: The current study is the first report from Iran that evaluates the prevalence and describes the clinical features of patients with sinonasal sarcoidosis in Iran. Materials and Methods: This cross-sectional descriptive study was performed on the eighty eight newly diagnosed and biopsy proven sarcoidosis patients who were suspected to have head and neck disorders. Sinonasal involvement of sarcoidosis was examined via Computed Tomography of Para-nasal Sinuses (CT PNS) imaging as well as rhinoscopy, and histopathologic examinations on the nasal or sinusitis mucosa biopsy sample. Data were analysed by Statistical Package for Social Sciences (SPSS) and differences between two groups were obtained using the χ2 test, the Mann-Whitney test and independent t-test with consideration of a statistically significant p-value of <0.05. Results: Sinonasal disorders were observed in 32 patients. Association of sinonasal and pulmonary sarcoidosis were confirmed in 18 of 32 SNS patients (56.25%). Rhinoscopy investigations demonstrated that the prevalent presenting signs were nasal crusting in 4 patients (14.3%), septal perforation in 3 patients (8.6%), mucosal hypertrophy in 9 patients (28.6%), synechia in 2 patients (5.7%), middle turbinate hypertrophy in 4 patients (11.4%) and submucosal nodule in 10 patients (31.4%). Conclusion: Endoscopic investigations indicated that the most frequent manifestation of SNS cases was inflammatory rhinosinusitis often with nodular lesions on the septum and turbinates. Further studies with bigger sample size are recommended in order to measure the sensitivity and specificity of nasal obstruction as a diagnostic parameter of sinonasal sarcoidosis patients of Iran. |
topic |
erythema nodosum granuloma methotrexate pulmonary sinusitis |
url |
https://jcdr.net/articles/PDF/12144/36637_CE[Ra1]_F(SL)_PF1(SJ_SL)_PF1(SJ_SHU)_PN(P).pdf |
work_keys_str_mv |
AT alisafavinaeini aspectsofthesinonasalsarcoidosismanifestationsiniran AT ardakiani aspectsofthesinonasalsarcoidosismanifestationsiniran AT shapoorsafari aspectsofthesinonasalsarcoidosismanifestationsiniran AT jahangirghorbani aspectsofthesinonasalsarcoidosismanifestationsiniran AT kimiataghavi aspectsofthesinonasalsarcoidosismanifestationsiniran AT mojganmotevallybashi aspectsofthesinonasalsarcoidosismanifestationsiniran AT mehdikazempourdizaji aspectsofthesinonasalsarcoidosismanifestationsiniran AT atefehabedini aspectsofthesinonasalsarcoidosismanifestationsiniran |
_version_ |
1724571372455198720 |