HEMOPHAGOSYTIC SYNDROME IN A CHILD WITH SEPSIS CAUSED BY SERRATIA PROTEAMACULANS

A clinical case of development of secondary hemophagocytic syndrome is presented on the background of sepsis caused by Serratia proteamaculans, in a child of monthly age, culminating in recovery. Hemophagocytic syndrome in the child developed on the 32nd day of life and was accompanied by fever, hep...

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Main Authors: Kh. S. Khaertynov, V. A. Anokhin, S. A. Lubin, A. Kh. Khaertynova
Format: Article
Language:Russian
Published: Journal Infectology 2019-03-01
Series:Žurnal Infektologii
Subjects:
Online Access:https://journal.niidi.ru/jofin/article/view/858
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spelling doaj-b4c9a206d47b471f804b97be1342d1982021-08-02T08:43:23ZrusJournal InfectologyŽurnal Infektologii 2072-67322019-03-011119810310.22625/2072-6732-2019-11-1-98-103711HEMOPHAGOSYTIC SYNDROME IN A CHILD WITH SEPSIS CAUSED BY SERRATIA PROTEAMACULANSKh. S. Khaertynov0V. A. Anokhin1S. A. Lubin2A. Kh. Khaertynova3Kazan State Medical University.Kazan State Medical University.City Children’s Clinical Hospital № 1.Kazan State Medical University.A clinical case of development of secondary hemophagocytic syndrome is presented on the background of sepsis caused by Serratia proteamaculans, in a child of monthly age, culminating in recovery. Hemophagocytic syndrome in the child developed on the 32nd day of life and was accompanied by fever, hepatosplenomegaly, anemia, thrombocytopenia, elevated blood levels of triglycerides and ferritin. Blood culture was positive for Serratia proteamaculans. Isolate of Serratia proteamaculans was resistant to aminopenicillins (including protected ones), 1–4 generations of cephalosporins and aminoglycosides but sensitive to ciprofloxacin and moderately sensitive to imipenem and meropenem. The duration of fever in the child was seven days, thrombocytopenia, hyperfertritinemia and hypertriglyceridemia – 28 days. The normalization of the indices of ferritin, triglycerides and platelets coincided with the reduction of bacteremia and high values of the C-reactive protein. The duration of bacteremia was three weeks: the isolation of Serratia proteamaculans from the blood occurred three times. Elevated levels of C-reactive protein in the blood were noted for 30 days. Reduced hemoglobin and red blood cells counts were noted for eight weeks. Positive dynamics of the hemophagocytic syndrome occurred as a result of measures aimed at treating sepsis – antibiotic therapy with imipenem in combination with ciprofloxacin, appointed by the decision of the medical commission on the basis of the sensitivity of Serratia proteamaculans to antibiotics, intravenous immunoglobulin, and infusion therapy. Glucocorticosteroids and cytotoxic agents (etoposide, cyclosporin A) have not been used in this case.https://journal.niidi.ru/jofin/article/view/858sepsisserratia proteamaculanshemophagocytic syndrome
collection DOAJ
language Russian
format Article
sources DOAJ
author Kh. S. Khaertynov
V. A. Anokhin
S. A. Lubin
A. Kh. Khaertynova
spellingShingle Kh. S. Khaertynov
V. A. Anokhin
S. A. Lubin
A. Kh. Khaertynova
HEMOPHAGOSYTIC SYNDROME IN A CHILD WITH SEPSIS CAUSED BY SERRATIA PROTEAMACULANS
Žurnal Infektologii
sepsis
serratia proteamaculans
hemophagocytic syndrome
author_facet Kh. S. Khaertynov
V. A. Anokhin
S. A. Lubin
A. Kh. Khaertynova
author_sort Kh. S. Khaertynov
title HEMOPHAGOSYTIC SYNDROME IN A CHILD WITH SEPSIS CAUSED BY SERRATIA PROTEAMACULANS
title_short HEMOPHAGOSYTIC SYNDROME IN A CHILD WITH SEPSIS CAUSED BY SERRATIA PROTEAMACULANS
title_full HEMOPHAGOSYTIC SYNDROME IN A CHILD WITH SEPSIS CAUSED BY SERRATIA PROTEAMACULANS
title_fullStr HEMOPHAGOSYTIC SYNDROME IN A CHILD WITH SEPSIS CAUSED BY SERRATIA PROTEAMACULANS
title_full_unstemmed HEMOPHAGOSYTIC SYNDROME IN A CHILD WITH SEPSIS CAUSED BY SERRATIA PROTEAMACULANS
title_sort hemophagosytic syndrome in a child with sepsis caused by serratia proteamaculans
publisher Journal Infectology
series Žurnal Infektologii
issn 2072-6732
publishDate 2019-03-01
description A clinical case of development of secondary hemophagocytic syndrome is presented on the background of sepsis caused by Serratia proteamaculans, in a child of monthly age, culminating in recovery. Hemophagocytic syndrome in the child developed on the 32nd day of life and was accompanied by fever, hepatosplenomegaly, anemia, thrombocytopenia, elevated blood levels of triglycerides and ferritin. Blood culture was positive for Serratia proteamaculans. Isolate of Serratia proteamaculans was resistant to aminopenicillins (including protected ones), 1–4 generations of cephalosporins and aminoglycosides but sensitive to ciprofloxacin and moderately sensitive to imipenem and meropenem. The duration of fever in the child was seven days, thrombocytopenia, hyperfertritinemia and hypertriglyceridemia – 28 days. The normalization of the indices of ferritin, triglycerides and platelets coincided with the reduction of bacteremia and high values of the C-reactive protein. The duration of bacteremia was three weeks: the isolation of Serratia proteamaculans from the blood occurred three times. Elevated levels of C-reactive protein in the blood were noted for 30 days. Reduced hemoglobin and red blood cells counts were noted for eight weeks. Positive dynamics of the hemophagocytic syndrome occurred as a result of measures aimed at treating sepsis – antibiotic therapy with imipenem in combination with ciprofloxacin, appointed by the decision of the medical commission on the basis of the sensitivity of Serratia proteamaculans to antibiotics, intravenous immunoglobulin, and infusion therapy. Glucocorticosteroids and cytotoxic agents (etoposide, cyclosporin A) have not been used in this case.
topic sepsis
serratia proteamaculans
hemophagocytic syndrome
url https://journal.niidi.ru/jofin/article/view/858
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AT vaanokhin hemophagosyticsyndromeinachildwithsepsiscausedbyserratiaproteamaculans
AT salubin hemophagosyticsyndromeinachildwithsepsiscausedbyserratiaproteamaculans
AT akhkhaertynova hemophagosyticsyndromeinachildwithsepsiscausedbyserratiaproteamaculans
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