Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties

3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained...

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Main Authors:	Kristina Mickevičienė, Rūta Baranauskaitė, Kristina Kantminienė, Maryna Stasevych, Olena Komarovska-Porokhnyavets, Volodymyr Novikov
Format:	Article
Language:	English
Published:	MDPI AG 2015-02-01
Series:	Molecules
Subjects:	heterocycles 1,4-naphthoquinone derivatives hydrazones antibacterial activity fungicides
Online Access:	http://www.mdpi.com/1420-3049/20/2/3170

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spelling	doaj-b561d1898aeb4e69b148cda8464f4d252020-11-25T00:28:30ZengMDPI AGMolecules1420-30492015-02-012023170318910.3390/molecules20023170molecules20023170Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline MoietiesKristina Mickevičienė0Rūta Baranauskaitė1Kristina Kantminienė2Maryna Stasevych3Olena Komarovska-Porokhnyavets4Volodymyr Novikov5Department of Physical and Inorganic Chemistry, Kaunas University of Technology, Kaunas 50254, LithuaniaDepartment of Organic Chemistry, Kaunas University of Technology, Kaunas 50254, LithuaniaDepartment of Physical and Inorganic Chemistry, Kaunas University of Technology, Kaunas 50254, LithuaniaDepartment of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, UkraineDepartment of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, UkraineDepartment of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, Ukraine3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained compounds with 2,3-dichloro-1,4-naphthoquinone. Five of the synthesized compounds exhibited good antimicrobial activity against Staphylococcus aureus and Mycobacterium luteum, whereas three compounds showed significant antifungal activity against Candida tenuis and Aspergillus niger.http://www.mdpi.com/1420-3049/20/2/3170heterocycles1,4-naphthoquinone derivativeshydrazonesantibacterial activityfungicides
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kristina Mickevičienė Rūta Baranauskaitė Kristina Kantminienė Maryna Stasevych Olena Komarovska-Porokhnyavets Volodymyr Novikov
spellingShingle	Kristina Mickevičienė Rūta Baranauskaitė Kristina Kantminienė Maryna Stasevych Olena Komarovska-Porokhnyavets Volodymyr Novikov Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties Molecules heterocycles 1,4-naphthoquinone derivatives hydrazones antibacterial activity fungicides
author_facet	Kristina Mickevičienė Rūta Baranauskaitė Kristina Kantminienė Maryna Stasevych Olena Komarovska-Porokhnyavets Volodymyr Novikov
author_sort	Kristina Mickevičienė
title	Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_short	Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_full	Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_fullStr	Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_full_unstemmed	Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_sort	synthesis and antimicrobial activity of n-substituted-β-amino acid derivatives containing 2-hydroxyphenyl, benzo[b]phenoxazine and quinoxaline moieties
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2015-02-01
description	3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained compounds with 2,3-dichloro-1,4-naphthoquinone. Five of the synthesized compounds exhibited good antimicrobial activity against Staphylococcus aureus and Mycobacterium luteum, whereas three compounds showed significant antifungal activity against Candida tenuis and Aspergillus niger.
topic	heterocycles 1,4-naphthoquinone derivatives hydrazones antibacterial activity fungicides
url	http://www.mdpi.com/1420-3049/20/2/3170
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Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties

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