Active maintenance of endothelial cells prevents kidney fibrosis

Active maintenance of endothelial cells prevents kidney fibrosis

Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents. Methods: We used a unilateral ureteral obstruction mouse model of kidney fibrosis to determine whether inhibition of sEH activity redu...

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Bibliographic Details
Main Authors: Seung Hee Yang, Yong Chul Kim, Jung Nam An, Jin Hyuk Kim, Juhoh Lee, Hee-Yoon Lee, Joo-Youn Cho, Jin Ho Paik, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee
Format: Article
Language:English
Published: The Korean Society of Nephrology 2017-12-01
Series:Kidney Research and Clinical Practice
Subjects:
Epithelial-mesenchymal transition
Endothelial dysfunction
Endothelial-to-mesenchymal transition
Kidney fibrosis
Soluble epoxide hydrolase
Online Access:https://doi.org/10.23876/j.krcp.2017.36.4.329

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https://doi.org/10.23876/j.krcp.2017.36.4.329

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