The Peptide ERα17p Is a GPER Inverse Agonist that Exerts Antiproliferative Effects in Breast Cancer Cells

The Peptide ERα17p Is a GPER Inverse Agonist that Exerts Antiproliferative Effects in Breast Cancer Cells

The inhibition of the G protein-coupled estrogen receptor (GPER) offers promising perspectives for the treatment of breast tumors. A peptide corresponding to part of the hinge region/AF2 domain of the human estrogen receptor α (ERα17p, residues 295–311) exerts anti-proliferative effects in various b...

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Bibliographic Details
Main Authors: Rosamaria Lappano, Christophe Mallet, Bruno Rizzuti, Fedora Grande, Giulia Raffaella Galli, Cillian Byrne, Isabelle Broutin, Ludivine Boudieu, Alain Eschalier, Yves Jacquot, Marcello Maggiolini
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
peptide
anti-proliferation
inverse agonist
desensitizer
GPER
SkBr3
breast cancer
Online Access:https://www.mdpi.com/2073-4409/8/6/590

Internet

https://www.mdpi.com/2073-4409/8/6/590

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