Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer

Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer

Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers. Moreover, aberrant histone ubiquitination can drive onco...

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Bibliographic Details
Main Authors: Lucile M-P Jeusset, Kirk J McManus
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cells
Subjects:
histone
H2A
H2B
ubiquitination
deubiquitination
E3 ubiquitin ligase
cancer
epigenetic therapy
synthetic lethality
epigenome editing
Online Access:https://www.mdpi.com/2073-4409/8/2/165

Internet

https://www.mdpi.com/2073-4409/8/2/165

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