Cyclosporin A-treated Dendritic Cells may affect the outcome of organ transplantation by decreasing CD4+CD25+ regulatory T cell proliferation

Cyclosporin A-treated Dendritic Cells may affect the outcome of organ transplantation by decreasing CD4+CD25+ regulatory T cell proliferation

One of the mechanisms for generation of tolerance involves immature dendritic cells (DCs) and a subpopulation of regulatory CD4+ CD25+ T lymphocytes (T REG). The purpose of this work was to analyze how Cyclosporine A (CsA), a widely used immunosuppressive drug, may affect T REG proliferation. Purifi...

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Bibliographic Details
Main Authors: Karina Pino-Lagos, Paula Michea, Daniela Sauma, Andrea Alba, Jorge Morales, María Rosa Bono, Alberto Fierro, Mario Rosemblatt
Format: Article
Language:English
Published: BMC 2010-01-01
Series:Biological Research
Subjects:
CD4+CD25+ regulatory T cell
Cyclosporine A
dendritic cells
transplant tolerance
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300010

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300010

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