Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

The Lon AAA+ protease (LonA) is a ubiquitous ATP-dependent proteolytic machine, which selectively degrades damaged proteins or native proteins carrying exposed motifs (degrons). Here we characterize the structural basis for substrate recognition and discrimination by the N-terminal domain (NTD) of L...

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Bibliographic Details
Main Authors: Shiou-Ru Tzeng, Yin-Chu Tseng, Chien-Chu Lin, Chia-Ying Hsu, Shing-Jong Huang, Yi-Ting Kuo, Chung-I Chang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
Lon AAA+ protease
N-terminal domain
degrons
misfolded proteins
protein aggregates
Meiothermus taiwanensis
Online Access:https://elifesciences.org/articles/64056

Internet

https://elifesciences.org/articles/64056

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