Myeloid derived suppressor cells as therapeutic target in hematological malignancies

Myeloid derived suppressor cells as therapeutic target in hematological malignancies

Myeloid derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that accumulate during pathological conditions such as cancer and are associated with a poor clinical outcome. MDSC expansion hampers the host anti-tumor immune response by inhibition of T cell prolifera...

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Bibliographic Details
Main Authors: Kim eDe Veirman, Els eVan Valckenborgh, Qods eLahmar, Xenia eGeeraerts, Elke eDe Bruyne, Eline eMenu, Ivan eVan Riet, Karin eVanderkerken, Jo A Van Ginderachter
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Oncology
Subjects:
Leukemia
Lymphoma
Multiple Myeloma
Stem Cell Transplantation
immune suppression mechanism
myeloid derived suppressor cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00349/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00349/full

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