Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases

To evaluate the therapeutic potential of stem cells for neurodegenerative diseases, emphasis should be placed on clarifying the characteristics of the various types of stem cells. Among stem cells, dental pulp stem cells (DPSCs) are a cell population that is rich in cell proliferation and multipoten...

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Main Authors: Tomoyuki Ueda, Masatoshi Inden, Taisei Ito, Hisaka Kurita, Isao Hozumi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00407/full
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spelling doaj-b63324d32d6b4086a78aec4a4624c6632020-11-25T02:09:24ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-05-011410.3389/fnins.2020.00407532435Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative DiseasesTomoyuki UedaMasatoshi IndenTaisei ItoHisaka KuritaIsao HozumiTo evaluate the therapeutic potential of stem cells for neurodegenerative diseases, emphasis should be placed on clarifying the characteristics of the various types of stem cells. Among stem cells, dental pulp stem cells (DPSCs) are a cell population that is rich in cell proliferation and multipotency. It has been reported that transplantation of DPSCs has protective effects against models of neurodegenerative diseases. The protective effects are not only through differentiation into the target cell type for the disease but are also related to trophic factors released from DPSCs. Recently, it has been reported that serum-free culture supernatant of dental pulp stem cell-conditioned medium (DPCM) contains various trophic factors and cytokines and that DPCM is effective for models of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS). Moreover, the use of stem cells from human exfoliated deciduous teeth (SHEDs) has been considered. SHEDs are derived from deciduous teeth that have been disposed of as medical waste. SHEDs have higher differentiation capacity and proliferation ability than DPSCs. In addition, the serum-free culture supernatant of SHEDs (SHED-CM) contains more trophic factors, cytokines, and biometals than DPCM and also promotes neuroprotection. The neuroprotective effect of DPSCs, including those from deciduous teeth, will be used as the seeds of therapeutic drugs for neurodegenerative diseases. SHEDs will be used for further cell therapy of neurodegenerative diseases in the future. In this paper, we focused on the characteristics of DPSCs and their potential for neurodegenerative diseases.https://www.frontiersin.org/article/10.3389/fnins.2020.00407/fulldental pulp stem cellsstem cells from human exfoliated deciduous teethconditioned mediumneurodegenerative diseasecell therapy
collection DOAJ
language English
format Article
sources DOAJ
author Tomoyuki Ueda
Masatoshi Inden
Taisei Ito
Hisaka Kurita
Isao Hozumi
spellingShingle Tomoyuki Ueda
Masatoshi Inden
Taisei Ito
Hisaka Kurita
Isao Hozumi
Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases
Frontiers in Neuroscience
dental pulp stem cells
stem cells from human exfoliated deciduous teeth
conditioned medium
neurodegenerative disease
cell therapy
author_facet Tomoyuki Ueda
Masatoshi Inden
Taisei Ito
Hisaka Kurita
Isao Hozumi
author_sort Tomoyuki Ueda
title Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases
title_short Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases
title_full Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases
title_fullStr Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases
title_full_unstemmed Characteristics and Therapeutic Potential of Dental Pulp Stem Cells on Neurodegenerative Diseases
title_sort characteristics and therapeutic potential of dental pulp stem cells on neurodegenerative diseases
publisher Frontiers Media S.A.
series Frontiers in Neuroscience
issn 1662-453X
publishDate 2020-05-01
description To evaluate the therapeutic potential of stem cells for neurodegenerative diseases, emphasis should be placed on clarifying the characteristics of the various types of stem cells. Among stem cells, dental pulp stem cells (DPSCs) are a cell population that is rich in cell proliferation and multipotency. It has been reported that transplantation of DPSCs has protective effects against models of neurodegenerative diseases. The protective effects are not only through differentiation into the target cell type for the disease but are also related to trophic factors released from DPSCs. Recently, it has been reported that serum-free culture supernatant of dental pulp stem cell-conditioned medium (DPCM) contains various trophic factors and cytokines and that DPCM is effective for models of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic Lateral Sclerosis (ALS). Moreover, the use of stem cells from human exfoliated deciduous teeth (SHEDs) has been considered. SHEDs are derived from deciduous teeth that have been disposed of as medical waste. SHEDs have higher differentiation capacity and proliferation ability than DPSCs. In addition, the serum-free culture supernatant of SHEDs (SHED-CM) contains more trophic factors, cytokines, and biometals than DPCM and also promotes neuroprotection. The neuroprotective effect of DPSCs, including those from deciduous teeth, will be used as the seeds of therapeutic drugs for neurodegenerative diseases. SHEDs will be used for further cell therapy of neurodegenerative diseases in the future. In this paper, we focused on the characteristics of DPSCs and their potential for neurodegenerative diseases.
topic dental pulp stem cells
stem cells from human exfoliated deciduous teeth
conditioned medium
neurodegenerative disease
cell therapy
url https://www.frontiersin.org/article/10.3389/fnins.2020.00407/full
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