Evaluate the effect of different doses for grape seed extract in mice
The aim of this study was to evaluate the effect of different doses for grape seeds extract in internal organs of mice. Histopathological, cytogentical and haematological studies were done to evaluate this effect. The study was done on (24) mice divided into four groups (6/group) for one month. Gro...
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University of Baghdad, College of Veterinary Medicine
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doaj-b65106af53d846bba13ab105eec7672a2021-08-04T20:29:32ZengUniversity of Baghdad, College of Veterinary MedicineThe Iraqi Journal of Veterinary Medicine1609-56932410-74092012-06-0136110.30539/iraqijvm.v36i1.552Evaluate the effect of different doses for grape seed extract in miceSanaa Kudair A . AL.Jeboory,0College of Veterinary Medicine, Baghdad University The aim of this study was to evaluate the effect of different doses for grape seeds extract in internal organs of mice. Histopathological, cytogentical and haematological studies were done to evaluate this effect. The study was done on (24) mice divided into four groups (6/group) for one month. Group one treated with PBS considered as control Negative, Group two treated with (100mg/kg B.W.) of grape seed extract, Group three treated with (200mg/kg B.W.) of grape seed extract, Group four treated with (300mg/kg B.W.) of grape seed extract. The results showed that (200, 300mg/kg B.W.) cause significant decrease in hematological, cytogentical parameters and severe histopathological changes while at dose (100mg/kg B.W.) induce immune pathological response organ with amelioration of haematological and cytogentical parameters. In conclusion the effect of grape seed extract was dose dependent that more severe toxicopathological changes appeared in haemtological, cytogentical and histopathological results at doses (200 and 300mg/kg B.W.) while at dose ( 100mg/kg B.W.) induce immunopathological response internal organs with amelioration of haematological and cytogentical parameters. https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/552Grape, toxicity, grape seed, Mice. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sanaa Kudair A . AL.Jeboory, |
spellingShingle |
Sanaa Kudair A . AL.Jeboory, Evaluate the effect of different doses for grape seed extract in mice The Iraqi Journal of Veterinary Medicine Grape, toxicity, grape seed, Mice. |
author_facet |
Sanaa Kudair A . AL.Jeboory, |
author_sort |
Sanaa Kudair A . AL.Jeboory, |
title |
Evaluate the effect of different doses for grape seed extract in mice |
title_short |
Evaluate the effect of different doses for grape seed extract in mice |
title_full |
Evaluate the effect of different doses for grape seed extract in mice |
title_fullStr |
Evaluate the effect of different doses for grape seed extract in mice |
title_full_unstemmed |
Evaluate the effect of different doses for grape seed extract in mice |
title_sort |
evaluate the effect of different doses for grape seed extract in mice |
publisher |
University of Baghdad, College of Veterinary Medicine |
series |
The Iraqi Journal of Veterinary Medicine |
issn |
1609-5693 2410-7409 |
publishDate |
2012-06-01 |
description |
The aim of this study was to evaluate the effect of different doses for grape seeds
extract in internal organs of mice. Histopathological, cytogentical and haematological
studies were done to evaluate this effect. The study was done on (24) mice divided into four
groups (6/group) for one month. Group one treated with PBS considered as control
Negative, Group two treated with (100mg/kg B.W.) of grape seed extract, Group three
treated with (200mg/kg B.W.) of grape seed extract, Group four treated with (300mg/kg
B.W.) of grape seed extract. The results showed that (200, 300mg/kg B.W.) cause
significant decrease in hematological, cytogentical parameters and severe histopathological
changes while at dose (100mg/kg B.W.) induce immune pathological response organ with
amelioration of haematological and cytogentical parameters. In conclusion the effect of
grape seed extract was dose dependent that more severe toxicopathological changes
appeared in haemtological, cytogentical and histopathological results at doses (200 and
300mg/kg B.W.) while at dose ( 100mg/kg B.W.) induce immunopathological response
internal organs with amelioration of haematological and cytogentical parameters.
|
topic |
Grape, toxicity, grape seed, Mice. |
url |
https://jcovm.uobaghdad.edu.iq/index.php/Iraqijvm/article/view/552 |
work_keys_str_mv |
AT sanaakudairaaljeboory evaluatetheeffectofdifferentdosesforgrapeseedextractinmice |
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1721221973122482176 |