Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates
<sec sec-type="objective"><title>Objective:</title><p>In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. A...
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2015-01-01
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doaj-b688095806024875b53cc988593b6f302020-11-25T01:49:51ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2015-01-010000010.1590/1516-4446-2014-1619S1516-44462015005041619Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlatesChristine LochnerNathaniel McGregorSian HemmingsBrian H. HarveyElsie BreetSonja SwanevelderDan J. Stein<sec sec-type="objective"><title>Objective:</title><p>In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and polymorphisms in dopaminergic genes has not been investigated in OCD.</p></sec><sec sec-type="methods"><title>Methods:</title><p>Clinical information and polymorphisms in key dopaminergic genes were compared between OCD patients with primary symmetry symptoms and those without.</p></sec><sec sec-type="results"><title>Results:</title><p>OCD patients with primary symmetry symptoms comprised 46.6% (n=210) of the sample (n=451), and were older (p < 0.01), had longer illness duration (p < 0.01), higher OCD severity scores (p = 0.01), and greater comorbidity (p < 0.01) than those without. In Caucasians (n=343), genotype frequency differed significantly between groups for <italic>ANKK1</italic> rs1800497, with more OCD patients with symmetry symptoms being homozygous for the <italic>A2</italic> (<italic>CC</italic>) genotype (χ<sup>2</sup> = 7.296; p = 0.026).</p></sec><sec sec-type="conclusion"><title>Conclusion:</title><p>Symmetry symptoms have some distinct clinical features and may represent a marker of severity in OCD. However, clinical associations, in combination with the association found with the <italic>ANKK1</italic> rs1800497 <italic>A2</italic> variant, suggest that primary symmetry symptoms may represent a distinctive clinical and psychobiological profile.</p></sec>http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015005041619&lng=en&tlng=enObsessive-compulsive disordersymptom subtypetraumageneticsdopamine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christine Lochner Nathaniel McGregor Sian Hemmings Brian H. Harvey Elsie Breet Sonja Swanevelder Dan J. Stein |
spellingShingle |
Christine Lochner Nathaniel McGregor Sian Hemmings Brian H. Harvey Elsie Breet Sonja Swanevelder Dan J. Stein Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates Brazilian Journal of Psychiatry Obsessive-compulsive disorder symptom subtype trauma genetics dopamine |
author_facet |
Christine Lochner Nathaniel McGregor Sian Hemmings Brian H. Harvey Elsie Breet Sonja Swanevelder Dan J. Stein |
author_sort |
Christine Lochner |
title |
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates |
title_short |
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates |
title_full |
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates |
title_fullStr |
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates |
title_full_unstemmed |
Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates |
title_sort |
symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates |
publisher |
Associação Brasileira de Psiquiatria (ABP) |
series |
Brazilian Journal of Psychiatry |
issn |
1809-452X |
publishDate |
2015-01-01 |
description |
<sec sec-type="objective"><title>Objective:</title><p>In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and polymorphisms in dopaminergic genes has not been investigated in OCD.</p></sec><sec sec-type="methods"><title>Methods:</title><p>Clinical information and polymorphisms in key dopaminergic genes were compared between OCD patients with primary symmetry symptoms and those without.</p></sec><sec sec-type="results"><title>Results:</title><p>OCD patients with primary symmetry symptoms comprised 46.6% (n=210) of the sample (n=451), and were older (p < 0.01), had longer illness duration (p < 0.01), higher OCD severity scores (p = 0.01), and greater comorbidity (p < 0.01) than those without. In Caucasians (n=343), genotype frequency differed significantly between groups for <italic>ANKK1</italic> rs1800497, with more OCD patients with symmetry symptoms being homozygous for the <italic>A2</italic> (<italic>CC</italic>) genotype (χ<sup>2</sup> = 7.296; p = 0.026).</p></sec><sec sec-type="conclusion"><title>Conclusion:</title><p>Symmetry symptoms have some distinct clinical features and may represent a marker of severity in OCD. However, clinical associations, in combination with the association found with the <italic>ANKK1</italic> rs1800497 <italic>A2</italic> variant, suggest that primary symmetry symptoms may represent a distinctive clinical and psychobiological profile.</p></sec> |
topic |
Obsessive-compulsive disorder symptom subtype trauma genetics dopamine |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462015005041619&lng=en&tlng=en |
work_keys_str_mv |
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