Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting

Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting

RGD-α-amanitin and isoDGR-α-amanitin conjugates were synthesized by joining integrin ligands to α-amanitin via various linkers and spacers. The conjugates were evaluated for their ability to inhibit biotinylated vitronectin binding to the purified αVβ3 receptor, retaining good binding affinity, in t...

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Bibliographic Details
Main Authors: Lizeth Bodero, Paula López Rivas, Barbara Korsak, Torsten Hechler, Andreas Pahl, Christoph Müller, Daniela Arosio, Luca Pignataro, Cesare Gennari, Umberto Piarulli
Format: Article
Language:English
Published: Beilstein-Institut 2018-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
antitumor agents
cancer
drug delivery
integrins
peptidomimetics
Online Access:https://doi.org/10.3762/bjoc.14.29

Internet

https://doi.org/10.3762/bjoc.14.29

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