Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest
Background: Gastrointestinal (GI) symptoms are prominent in patients with major depressive disorder (MDD). Previous studies have reported brain structural and functional changes in both MDD and digestive system diseases but it remains unclear whether MDD patients with GI symptoms have brain imaging...
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doaj-b6e5822b5bec4c71835316e56f39d37b2021-05-26T04:32:17ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-05-011210.3389/fpsyt.2021.636820636820Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at RestMeiqi Yan0Jindong Chen1Feng Liu2Huabing Li3Renzhi Huang4Yanqing Tang5Jingping Zhao6Wenbin Guo7Wenbin Guo8Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, ChinaHunan Key Laboratory of Children's Psychological Development and Brain Cognitive Science, Changsha, ChinaDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, ChinaBackground: Gastrointestinal (GI) symptoms are prominent in patients with major depressive disorder (MDD). Previous studies have reported brain structural and functional changes in both MDD and digestive system diseases but it remains unclear whether MDD patients with GI symptoms have brain imaging changes.Methods: We recruited 35 MDD patients with GI symptoms, 17 MDD patients without GI symptoms and 28 age-, gender-, and education-matched healthy controls. All participants were scanned by resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo).Results: The GI group showed higher total HRSD-17 scores, anxiety/somatization, weight loss, and sleep disturbance scores compared to the non-GI group. We found increased ReHo in the right inferior parietal gyrus (IPL), bilateral supplementary motor area (SMA), bilateral cerebellum Crus II, left inferior frontal gyrus (IFG), and bilateral superior medial frontal cortex (SMFC) and decreased ReHo in the right posterior cingulate cortex (PCC), bilateral cuneus, and left middle occipital gyrus (MOG) in patients with GI symptoms relative to the HCs. The GI group showed higher ReHo values in the bilateral precuneus than the non-GI group.Conclusion: MDD patients with GI symptoms showed a greater severity of symptoms than MDD patients without GI symptoms, particularly in terms of anxiety/somatization, weight loss, and sleep disturbances. Increased activity in the default-mode network might be associated with GI symptoms in MDD patients.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.636820/fullmajor depressive disorderregional homogeneitygastrointestinal symptomsmagnetic resonance imagingresting state |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meiqi Yan Jindong Chen Feng Liu Huabing Li Renzhi Huang Yanqing Tang Jingping Zhao Wenbin Guo Wenbin Guo |
spellingShingle |
Meiqi Yan Jindong Chen Feng Liu Huabing Li Renzhi Huang Yanqing Tang Jingping Zhao Wenbin Guo Wenbin Guo Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest Frontiers in Psychiatry major depressive disorder regional homogeneity gastrointestinal symptoms magnetic resonance imaging resting state |
author_facet |
Meiqi Yan Jindong Chen Feng Liu Huabing Li Renzhi Huang Yanqing Tang Jingping Zhao Wenbin Guo Wenbin Guo |
author_sort |
Meiqi Yan |
title |
Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
title_short |
Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
title_full |
Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
title_fullStr |
Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
title_full_unstemmed |
Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest |
title_sort |
disrupted regional homogeneity in major depressive disorder with gastrointestinal symptoms at rest |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2021-05-01 |
description |
Background: Gastrointestinal (GI) symptoms are prominent in patients with major depressive disorder (MDD). Previous studies have reported brain structural and functional changes in both MDD and digestive system diseases but it remains unclear whether MDD patients with GI symptoms have brain imaging changes.Methods: We recruited 35 MDD patients with GI symptoms, 17 MDD patients without GI symptoms and 28 age-, gender-, and education-matched healthy controls. All participants were scanned by resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo).Results: The GI group showed higher total HRSD-17 scores, anxiety/somatization, weight loss, and sleep disturbance scores compared to the non-GI group. We found increased ReHo in the right inferior parietal gyrus (IPL), bilateral supplementary motor area (SMA), bilateral cerebellum Crus II, left inferior frontal gyrus (IFG), and bilateral superior medial frontal cortex (SMFC) and decreased ReHo in the right posterior cingulate cortex (PCC), bilateral cuneus, and left middle occipital gyrus (MOG) in patients with GI symptoms relative to the HCs. The GI group showed higher ReHo values in the bilateral precuneus than the non-GI group.Conclusion: MDD patients with GI symptoms showed a greater severity of symptoms than MDD patients without GI symptoms, particularly in terms of anxiety/somatization, weight loss, and sleep disturbances. Increased activity in the default-mode network might be associated with GI symptoms in MDD patients. |
topic |
major depressive disorder regional homogeneity gastrointestinal symptoms magnetic resonance imaging resting state |
url |
https://www.frontiersin.org/articles/10.3389/fpsyt.2021.636820/full |
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