Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons

Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons

Abstract Background MBD5, encoding the methyl-CpG-binding domain 5 protein, has been proposed as a necessary and sufficient driver of the 2q23.1 microdeletion syndrome. De novo missense and protein-truncating variants from exome sequencing studies have directly implicated MBD5 in the etiology of aut...

Full description

Bibliographic Details
Main Authors: Catarina M. Seabra, Tatsiana Aneichyk, Serkan Erdin, Derek J. C. Tai, Celine E. F. De Esch, Parisa Razaz, Yu An, Poornima Manavalan, Ashok Ragavendran, Alexei Stortchevoi, Clemer Abad, Juan I. Young, Patricia Maciel, Michael E. Talkowski, James F. Gusella
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Autism
Subjects:
MBD5
Autism spectrum disorder
NDD
CRISPR
Mouse
Neurons
Online Access:http://link.springer.com/article/10.1186/s13229-020-00354-1

Internet

http://link.springer.com/article/10.1186/s13229-020-00354-1

Similar Items