Inflammation in the Human Periodontium Induces Downregulation of the α<sub>1</sub>- and β<sub>1</sub>-Subunits of the sGC in Cementoclasts

Inflammation in the Human Periodontium Induces Downregulation of the α<sub>1</sub>- and β<sub>1</sub>-Subunits of the sGC in Cementoclasts

Nitric oxide (NO) binds to soluble guanylyl cyclase (sGC), activates it in a reduced oxidized heme iron state, and generates cyclic Guanosine Monophosphate (cGMP), which results in vasodilatation and inhibition of osteoclast activity. In inflammation, sGC is oxidized and becomes insensitive to NO. N...

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Bibliographic Details
Main Authors: Yüksel Korkmaz, Behrus Puladi, Kerstin Galler, Peer W. Kämmerer, Agnes Schröder, Lina Gölz, Tim Sparwasser, Wilhelm Bloch, Andreas Friebe, James Deschner
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
nitric oxide
soluble guanylyl cyclase
cGMP
cementoclasts
cementum
osteoclasts
Online Access:https://www.mdpi.com/1422-0067/22/2/539

Internet

https://www.mdpi.com/1422-0067/22/2/539

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