Differential Effects of Methyl-4-Phenylpyridinium Ion, Rotenone, and Paraquat on Differentiated SH-SY5Y Cells

Paraquat (PQ), a cationic nonselective bipyridyl herbicide, has been used as neurotoxicant to modulate Parkinson’s disease in laboratory settings. Other compounds like rotenone (ROT), a pesticide, and 1-methyl-4-phenylpyridinium ion (MPP+) have been widely used as neurotoxicants. We compared the tox...

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Bibliographic Details
Main Authors: João Barbosa Martins, Maria de Lourdes Bastos, Félix Carvalho, João Paulo Capela
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2013/347312