CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells

CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells

Notch signaling provides an important cue in the mammalian developmental process. It is a key player in T cell development and function. Notch ligands such as Delta-like ligands (DLL) 1, 3, 4, and JAG1, 2 can impact Notch signaling positively or negatively, by trans-activation or cis-inhibition. Tra...

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Bibliographic Details
Main Authors: Ankita Mitra, Sudarvili Shanthalingam, Heather L. Sherman, Khushboo Singh, Mine Canakci, Joe A. Torres, Rebecca Lawlor, Yong Ran, Todd E. Golde, Lucio Miele, Sankaran Thayumanavan, Lisa M. Minter, Barbara A. Osborne
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
Notch1
DLL1
DLL4
JAG1
CD28
cis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00735/full

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