UHPLC-MS/MS Determination, Pharmacokinetic, and Bioavailability Study of Taxifolin in Rat Plasma after Oral Administration of its Nanodispersion

A rapid and sensitive LC-MS/MS method based on the Triple Quad system has been developed and validated for the determination and pharmacokinetics of taxifolin and its nanodispersion in rat plasma. Taxifolin plasma samples along with butylparaben (internal standard) were pre-treated by liquid-liquid...

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Bibliographic Details
Main Authors: Chun-Juan Yang, Zhi-Bin Wang, Ying-Ying Mi, Ming-Jie Gao, Jin-Nan Lv, Yong-Hai Meng, Bing-You Yang, Hai-Xue Kuang
Format: Article
Published: MDPI AG 2016-04-01
Online Access:http://www.mdpi.com/1420-3049/21/4/494