Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9

Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9

Deficiency of otoferlin causes profound prelingual deafness in humans and animal models. Here, we closely analyzed developmental deficits and degenerative mechanisms in Otof knock-out (Otof–/–) mice over the course of 48 weeks. We found otoferlin to be required for proper synapse development in the...

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Bibliographic Details
Main Authors: Ursula Stalmann, Albert Justin Franke, Hanan Al-Moyed, Nicola Strenzke, Ellen Reisinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
inner hair cells
outer hair cells
synapse maturation
degeneration
otoacoustic emissions
hearing loss
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.677543/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.677543/full

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