Reactivation of Latent Toxoplasmosis in a Schizophrenia Pa-tient: A Case Report
Schizophrenia is a serious mental disorder characterized by chronic relapsing episodes of psychosis. The disease is multifactorial, where infections, genetic vulnerability and environmental factors are involved in the development of the illness. Toxoplasma gondii is one of the parasites that has lo...
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Tehran University of Medical Sciences
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doaj-b7ecb14b9a36426abcbf8cd5cc9eabf62021-09-11T05:04:41ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2021-08-0116310.18502/ijpa.v16i3.7106Reactivation of Latent Toxoplasmosis in a Schizophrenia Pa-tient: A Case ReportWathiqah Wahid0Anis Safirah Mohammad Zahariluddin1Zuri Shahidii Kadir2Shalisah Sharip3Zulkarnain Md Idris4Emelia Osman5Department of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, MalaysiaDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, MalaysiaDepartment of Psychiatry, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, MalaysiaDepartment of Psychiatry, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, MalaysiaDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, MalaysiaDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Cheras, Kuala Lumpur, Malaysia Schizophrenia is a serious mental disorder characterized by chronic relapsing episodes of psychosis. The disease is multifactorial, where infections, genetic vulnerability and environmental factors are involved in the development of the illness. Toxoplasma gondii is one of the parasites that has long been known associated with schizophrenia in many studies. To date, there is growing evidence of association between T. gondii infections and schizophrenia. Herein we report a rare case of reactivated toxoplasmosis in a schizophrenia individual. This patient was incidentally diagnosed with reactivated T. gondii infection. He denied any symptoms of toxoplasmosis but experienced a mild psychiatric auditory hallucination. Serology test for T. gondii immunoglobulin antibodies measured a high positive IgG titer (135.9 IU/ml) and negative for IgM. Interestingly, nested PCR exhibited a positive result for the type I strain of T. gondii dense granular (GRA) 7 gene (GRA7). This case highlights the detection of probable reactivation of toxoplasmosis in an immunocompetent schizophrenic patient without psychiatric treatment-resistant and remains asymptomatic for toxoplasmosis. Both serology and molecular tools have been a helpful aid in establishing the diagnosis. Nonetheless, early detection as in this case may aid the patient management in the future. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3099ToxoplasmosisSchizophreniaReactivatedSerology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wathiqah Wahid Anis Safirah Mohammad Zahariluddin Zuri Shahidii Kadir Shalisah Sharip Zulkarnain Md Idris Emelia Osman |
spellingShingle |
Wathiqah Wahid Anis Safirah Mohammad Zahariluddin Zuri Shahidii Kadir Shalisah Sharip Zulkarnain Md Idris Emelia Osman Reactivation of Latent Toxoplasmosis in a Schizophrenia Pa-tient: A Case Report Iranian Journal of Parasitology Toxoplasmosis Schizophrenia Reactivated Serology |
author_facet |
Wathiqah Wahid Anis Safirah Mohammad Zahariluddin Zuri Shahidii Kadir Shalisah Sharip Zulkarnain Md Idris Emelia Osman |
author_sort |
Wathiqah Wahid |
title |
Reactivation of Latent Toxoplasmosis in a Schizophrenia Pa-tient: A Case Report |
title_short |
Reactivation of Latent Toxoplasmosis in a Schizophrenia Pa-tient: A Case Report |
title_full |
Reactivation of Latent Toxoplasmosis in a Schizophrenia Pa-tient: A Case Report |
title_fullStr |
Reactivation of Latent Toxoplasmosis in a Schizophrenia Pa-tient: A Case Report |
title_full_unstemmed |
Reactivation of Latent Toxoplasmosis in a Schizophrenia Pa-tient: A Case Report |
title_sort |
reactivation of latent toxoplasmosis in a schizophrenia pa-tient: a case report |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Parasitology |
issn |
1735-7020 2008-238X |
publishDate |
2021-08-01 |
description |
Schizophrenia is a serious mental disorder characterized by chronic relapsing episodes of psychosis. The disease is multifactorial, where infections, genetic vulnerability and environmental factors are involved in the development of the illness. Toxoplasma gondii is one of the parasites that has long been known associated with schizophrenia in many studies. To date, there is growing evidence of association between T. gondii infections and schizophrenia. Herein we report a rare case of reactivated toxoplasmosis in a schizophrenia individual. This patient was incidentally diagnosed with reactivated T. gondii infection. He denied any symptoms of toxoplasmosis but experienced a mild psychiatric auditory hallucination. Serology test for T. gondii immunoglobulin antibodies measured a high positive IgG titer (135.9 IU/ml) and negative for IgM. Interestingly, nested PCR exhibited a positive result for the type I strain of T. gondii dense granular (GRA) 7 gene (GRA7). This case highlights the detection of probable reactivation of toxoplasmosis in an immunocompetent schizophrenic patient without psychiatric treatment-resistant and remains asymptomatic for toxoplasmosis. Both serology and molecular tools have been a helpful aid in establishing the diagnosis. Nonetheless, early detection as in this case may aid the patient management in the future.
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topic |
Toxoplasmosis Schizophrenia Reactivated Serology |
url |
https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3099 |
work_keys_str_mv |
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1717757096606302208 |