Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis.

Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis.

Silicosis is an occupational lung disease with no effective treatment. We hypothesized that dasatinib, a tyrosine kinase inhibitor, might exhibit therapeutic efficacy in silica-induced pulmonary fibrosis. Silicosis was induced in C57BL/6 mice by a single intratracheal administration of silica partic...

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Bibliographic Details
Main Authors: Fernanda Ferreira Cruz, Lucas Felipe Bastos Horta, Lígia de Albuquerque Maia, Miquéias Lopes-Pacheco, André Benedito da Silva, Marcelo Marco Morales, Cassiano Felippe Gonçalves-de-Albuquerque, Christina Maeda Takiya, Hugo Caire de Castro-Faria-Neto, Patricia Rieken Macedo Rocco
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4720427?pdf=render

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http://europepmc.org/articles/PMC4720427?pdf=render

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