THE MOLECULAR PATHOGENESIS OF BLADDER CANCER

THE MOLECULAR PATHOGENESIS OF BLADDER CANCER

The review describes the current views on urothelial carcinoma carcinogenesis. Based on the up-todate genetic studies, molecular pathways determining the development of superficial and invasive bladder cancers are considered. It was demonstrated that the development of noninvasive bladder tumors occ...

Full description

Bibliographic Details
Main Authors: M. V. Nemtsova, N. E. Kushlinskii
Format: Article
Language:Russian
Published: MONIKI 2016-02-01
Series:Alʹmanah Kliničeskoj Mediciny
Subjects:
superficial and invasive bladder cancer
mutations
gene
fgfr3
тр53
monoclonal and oligoclonal bladder tumors
Online Access:https://www.almclinmed.ru/jour/article/view/82
id doaj-b8370de9a9fd40849983b8ef3d189a78
record_format Article
spelling doaj-b8370de9a9fd40849983b8ef3d189a782021-07-28T21:11:18ZrusMONIKIAlʹmanah Kliničeskoj Mediciny2072-05052587-92942016-02-01041798810.18786/2072-0505-2015-41-79-8882THE MOLECULAR PATHOGENESIS OF BLADDER CANCERM. V. Nemtsova0N. E. Kushlinskii1Research Centre for Medical Genetics, MoscowN.N. Blokhin Russian Cancer Research Center, MoscowThe review describes the current views on urothelial carcinoma carcinogenesis. Based on the up-todate genetic studies, molecular pathways determining the development of superficial and invasive bladder cancers are considered. It was demonstrated that the development of noninvasive bladder tumors occurred predominantly through oncogenes activation, while the genesis of invasive cancer is based on inactivation of tumor suppressor genes. Principal mechanisms of multiple and recurrent bladder tumors development are discussed including its monoclonal and oligoclonal models.One of the most promising nowadays approaches is the determination of new generation markers, such as molecular genetic abnormalities in the hereditary apparatus of the cell underlying its malignant transformation. Molecular markers' panels used for diagnostics, prognosis, and monitoring of urothelial carcinoma patients are analyzed.https://www.almclinmed.ru/jour/article/view/82superficial and invasive bladder cancermutationsgenefgfr3тр53monoclonal and oligoclonal bladder tumors
collection DOAJ
language Russian
format Article
sources DOAJ
author M. V. Nemtsova
N. E. Kushlinskii
spellingShingle M. V. Nemtsova
N. E. Kushlinskii
THE MOLECULAR PATHOGENESIS OF BLADDER CANCER
Alʹmanah Kliničeskoj Mediciny
superficial and invasive bladder cancer
mutations
gene
fgfr3
тр53
monoclonal and oligoclonal bladder tumors
author_facet M. V. Nemtsova
N. E. Kushlinskii
author_sort M. V. Nemtsova
title THE MOLECULAR PATHOGENESIS OF BLADDER CANCER
title_short THE MOLECULAR PATHOGENESIS OF BLADDER CANCER
title_full THE MOLECULAR PATHOGENESIS OF BLADDER CANCER
title_fullStr THE MOLECULAR PATHOGENESIS OF BLADDER CANCER
title_full_unstemmed THE MOLECULAR PATHOGENESIS OF BLADDER CANCER
title_sort molecular pathogenesis of bladder cancer
publisher MONIKI
series Alʹmanah Kliničeskoj Mediciny
issn 2072-0505
2587-9294
publishDate 2016-02-01
description The review describes the current views on urothelial carcinoma carcinogenesis. Based on the up-todate genetic studies, molecular pathways determining the development of superficial and invasive bladder cancers are considered. It was demonstrated that the development of noninvasive bladder tumors occurred predominantly through oncogenes activation, while the genesis of invasive cancer is based on inactivation of tumor suppressor genes. Principal mechanisms of multiple and recurrent bladder tumors development are discussed including its monoclonal and oligoclonal models.One of the most promising nowadays approaches is the determination of new generation markers, such as molecular genetic abnormalities in the hereditary apparatus of the cell underlying its malignant transformation. Molecular markers' panels used for diagnostics, prognosis, and monitoring of urothelial carcinoma patients are analyzed.
topic superficial and invasive bladder cancer
mutations
gene
fgfr3
тр53
monoclonal and oligoclonal bladder tumors
url https://www.almclinmed.ru/jour/article/view/82
work_keys_str_mv AT mvnemtsova themolecularpathogenesisofbladdercancer
AT nekushlinskii themolecularpathogenesisofbladdercancer
AT mvnemtsova molecularpathogenesisofbladdercancer
AT nekushlinskii molecularpathogenesisofbladdercancer
_version_ 1721262498069348352

Similar Items