Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy
Lactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy indu...
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Wolters Kluwer Medknow Publications
2015-01-01
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Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=9;spage=1457;epage=1462;aulast=Yang |
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doaj-b859e86d0b024f5db1b25125fd1b53a52020-11-25T03:32:27ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-011091457146210.4103/1673-5374.165516Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathyNan YangHe LiuYao JiangJi ZhengDong-mei LiChao JiYan-yong LiuPing-ping ZuoLactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy induced by carbon tetrachloride. Immunohistochemistry showed that lactulose treatment promoted neurogenesis and increased the number of neurons and astrocytes in the hippocampus. Moreover, lactulose-treated rats showed shorter escape latencies than model rats in the Morris water maze, indicating that lactulose improved the cognitive impairments caused by hepatic encephalopathy. The present findings suggest that lactulose effectively improves cognitive function by enhancing neuroplasticity in a rat model of early hepatic encephalopathy.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=9;spage=1457;epage=1462;aulast=Yangnerve regeneration; brain injury; hepatic encephalopathy; lactulose; neuroplasticity; neurogenesis; Morris water maze; cognition; rats; neuronal nuclei; glial fibrillary acidic protein; NSFC grants; neural regeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nan Yang He Liu Yao Jiang Ji Zheng Dong-mei Li Chao Ji Yan-yong Liu Ping-ping Zuo |
spellingShingle |
Nan Yang He Liu Yao Jiang Ji Zheng Dong-mei Li Chao Ji Yan-yong Liu Ping-ping Zuo Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy Neural Regeneration Research nerve regeneration; brain injury; hepatic encephalopathy; lactulose; neuroplasticity; neurogenesis; Morris water maze; cognition; rats; neuronal nuclei; glial fibrillary acidic protein; NSFC grants; neural regeneration |
author_facet |
Nan Yang He Liu Yao Jiang Ji Zheng Dong-mei Li Chao Ji Yan-yong Liu Ping-ping Zuo |
author_sort |
Nan Yang |
title |
Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy |
title_short |
Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy |
title_full |
Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy |
title_fullStr |
Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy |
title_full_unstemmed |
Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy |
title_sort |
lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy |
publisher |
Wolters Kluwer Medknow Publications |
series |
Neural Regeneration Research |
issn |
1673-5374 |
publishDate |
2015-01-01 |
description |
Lactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy induced by carbon tetrachloride. Immunohistochemistry showed that lactulose treatment promoted neurogenesis and increased the number of neurons and astrocytes in the hippocampus. Moreover, lactulose-treated rats showed shorter escape latencies than model rats in the Morris water maze, indicating that lactulose improved the cognitive impairments caused by hepatic encephalopathy. The present findings suggest that lactulose effectively improves cognitive function by enhancing neuroplasticity in a rat model of early hepatic encephalopathy. |
topic |
nerve regeneration; brain injury; hepatic encephalopathy; lactulose; neuroplasticity; neurogenesis; Morris water maze; cognition; rats; neuronal nuclei; glial fibrillary acidic protein; NSFC grants; neural regeneration |
url |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=9;spage=1457;epage=1462;aulast=Yang |
work_keys_str_mv |
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