Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation

Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation

The G protein-coupled receptor Smoothened (Smo) is the signal transducer of the Sonic Hedgehog (Shh) pathway. Smo signals through G protein-dependent and -independent routes, with G protein-independent canonical signaling to Gli effectors requiring Smo accumulation in the primary cilium. The mechani...

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Bibliographic Details
Main Authors: Angela M. Arensdorf, Miriam E. Dillard, Jacob M. Menke, Matthew W. Frank, Charles O. Rock, Stacey K. Ogden
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
Sonic Hedgehog
primary cilium
signal transduction
Smoothened
phospholipase A2
arachidonic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306757

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http://www.sciencedirect.com/science/article/pii/S2211124717306757

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