Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats.

OBJECTIVES: Spontaneously hypertensive rats (SHR) have been used frequently as a model for human essential hypertension. However, both the SHR and its normotensive control, the Wistar Kyoto rat (WKY), consist of genetically different sublines. We tested the hypothesis that the pathophysiology of vas...

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Bibliographic Details
Main Authors: Erik N T P Bakker, Gergely Groma, Léon J A Spijkers, Judith de Vos, Angela van Weert, Henk van Veen, Vincent Everts, Silvia M Arribas, Ed VanBavel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4175999?pdf=render