Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity.

Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity.

Insect voltage-gated sodium (Nav) channels are formed by a well-known pore-forming α-subunit encoded by para-like gene and ancillary subunits related to TipE from the mutation "temperature-induced-paralysis locus E." The role of these ancillary subunits in the modulation of biophysical and...

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Bibliographic Details
Main Authors: Céline M Bourdin, Bénédicte Moignot, Lingxin Wang, Laurence Murillo, Marjorie Juchaux, Sophie Quinchard, Bruno Lapied, Nathalie C Guérineau, Ke Dong, Christian Legros
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3744522?pdf=render

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http://europepmc.org/articles/PMC3744522?pdf=render

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