Ipilimumab and Its Derived EGFR Aptamer-Based Conjugate Induce Efficient NK Cell Activation against Cancer Cells

Ipilimumab and Its Derived EGFR Aptamer-Based Conjugate Induce Efficient NK Cell Activation against Cancer Cells

The immune checkpoint CTLA-4 (cytotoxic T-lymphocyte-antigen 4), which inhibits the co-stimulatory CD28 signal on T cells, has been recently found expressed on other cell populations, such as tumor and natural killer (NK) cells. We tested for the first time the effects of ipilimumab, the human anti-...

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Bibliographic Details
Main Authors: Margherita Passariello, Simona Camorani, Cinzia Vetrei, Stefania Ricci, Laura Cerchia, Claudia De Lorenzo
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
egfr
ctla-4
bispecific
natural killer cells
ipilimumab
aptamer
cancer therapy
Online Access:https://www.mdpi.com/2072-6694/12/2/331

Internet

https://www.mdpi.com/2072-6694/12/2/331

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